终末期肾病维持性血液透析患者高磷血症与异位钙化的临床研究  

Clinical Study of Hyperphosphatemia and Ectopic Calcification in Maintenance Hemodialysis Patients with End-stage Renal Disease

作　　者：李冠昉 周兵 朱赞东 李丹 Li Guanfang;Zhou Bing;Zhu Zandong;Li Dan(Department of Nephrology and Rheumatology,Shaoguan No.1 People's Hospital,Shaoguan 512000)

机构地区：[1]韶关市第一人民医院肾病风湿科,韶关512000

出　　处：《数理医药学杂志》2021年第12期1768-1770,共3页Journal of Mathematical Medicine

基　　金：韶关市卫生计生科研项目(Y19085)。

摘　　要：目的:了解终末期肾病高磷血症患者异位钙化情况及其影响因素,为其制定合理的治疗方案提供依据。方法:选取2019年1月~2019年12月某院治疗的83例终末期肾病血液透析患者,根据血磷水平将其分为高磷血症组41例,血磷正常组42例。比较两组患者一般资料、血钙、胆固醇、高血压发病率及心脏瓣膜钙化率间差异,使用多因素回归分析探讨相关变量与高磷血症患病率间关系。结果:本次研究中,高磷血症组血钙浓度为(2.12±0.22)mmol/L、胆固醇为(4.6±0.91)mmol/L、高血压发病率达29%、心脏瓣膜钙化率达34%,血磷正常组血钙浓度为(1.97±0.27)mmol/L、胆固醇为(1.21±0.81)mmol/L、高血压发病率达9%、心脏瓣膜钙化率达12%,两组比较,差异均有统计学意义(P<0.05)。多因素结果分析中,血钙、高血压、心脏瓣膜钙化、胆固醇是高磷血症的独立影响因素(P<0.05)。结论:终末期肾病高磷血症患者血钙水平、心脏瓣膜钙化、高血压是其独立危险因素,在患者治疗过程中注意患者的磷、钙失常。Objective:To understand the ectopic calcification and its influencing factors in patients with hyperphosphatemia of end-stage renal disease,so as to provide basis for formulating a reasonable treatment plan.Methods:We selected 83 end-stage renal disease hemodialysis patients treated in our hospital from January 2019 to December 2019 and divided them into a hyperphosphatemia group with 41 cases and a normal blood phosphorus group with 42 cases according to their blood phosphorus levels.The differences in general data,blood calcium,cholesterol,incidence of hypertension,and heart valve calcification rates between the two groups of patients were compared.Multivariate regression analysis was used to explore the relationship between related variables and the prevalence of hyperphosphatemia.Results:In this study,the blood calcium concentration of the hyperphosphatemia group was(2.12±0.22)mmol/L,cholesterol was(4.6±0.91)mmol/L,the incidence of hypertension was 29%,and the calcification rate of heart valves was 34%.The blood calcium concentration in the normal blood phosphorus group was(1.97±0.27)mmol/L,cholesterol was(1.21±0.81)mmol/L,the incidence of hypertension reached 9%,and the rate of heart valve calcification reached 12%.The differences between the two groups were all Statistically significant(P<0.05).In multivariate analysis,blood calcium,hypertension,cardiac valve calcification and cholesterol were independent influencing factors of hyperphosphatemia(P<0.05).Conclusion:Blood calcium level,cardiac valve calcification and hypertension are independent risk factors in patients with hyperphosphatemia of end-stage renal disease.Attention should be paid to the disorder of phosphorus and calcium in the process of treatment.

关 键 词：高磷血症 异位钙化 终末期肾病 

分 类 号：R692[医药卫生—泌尿科学]