河北省不同地理环境上尿路结石成分分布特点研究  

Geographic Variability of Upper Urinary Tract Stone Constituents in Hebei Adults

作　　者：常学良[1] 王亚轩[1] 李景东[1] 张艳平[1] 滕志海[1] 韩振伟[1] CHANG Xueliang;WANG Yaxuan;LI Jingdong;ZHANG Yanping;TENG Zhihai;HAN Zhenwei(Department of Urology,the Second Hospital of Hebei Medical University,Shijiazhuang 050000,China)

机构地区：[1]河北医科大学第二医院泌尿外科,河北省石家庄市050000

出　　处：《中国全科医学》2022年第2期171-174,共4页Chinese General Practice

基　　金：河北省卫生健康委医学科学研究课题计划项目(20190048,20210756)。

摘　　要：背景泌尿系结石是泌尿系统常见病、多发病,其中上尿路结石最为常见,给患者造成沉重负担。上尿路结石成因复杂,与性别、年龄、地理位置、气候、饮食等密切相关,不同地理环境患者的结石成分是否存在差异仍不清楚。目的分析河北省不同地理环境上尿路结石成分,为临床上尿路结石的治疗及预防提供依据。方法收集2019年于河北医科大学第二医院门诊进行体外冲击波碎石和住院手术取出结石的患者资料,获取1192例患者的上尿路结石标本,使用红外光谱法对结石成分进行定量和定性分析,分析河北省山区、平原、沿海地区患者的结石成分特点。结果上尿路结石患者高发年龄为30~70岁,男女比例约为1.75∶1,肾结石与输尿管结石占比相当(约为1.1∶1),结石成分以混合性结石为主(61.5%)。三种地理环境上尿路结石均以含钙结石为主,以一水草酸钙为最多。感染性结石在山区、平原地区及沿海地区的占比比较,差异无统计学意义(P>0.05)。平原地区的尿酸结石占比与山区及沿海地区比较,差异均有统计学意义(P<0.05)。结论河北省三种地理环境上尿路结石分布均以含钙结石为主,山区及沿海地区尿酸结石占比较高,需引起泌尿外科医生的注意。Background Urinary stones are a common and frequently-occurring disease of the urinary system,among which upper urinary tract stones are the most common,imposing a heavy burden on patients.The causes of upper urinary tract stones are complex,which are closely associated with gender,age,geographic condition,climate,diet,and so on.However,it is still unclear whether upper urinary stone constituents vary by geographical conditions.Objective To analyze the constituents of upper urinary tract stones among adults in different geographic regions of Hebei,providing evidence for clinical treatment and prevention of upper urinary tract stones.Methods Outpatients and inpatients(n=1192,≥18 years old)with upper urinary calculis who were from three geographical regions(mountainous,plain and coastal)of Hebei were selected from the Second Hospital of Hebei Medical University in 2019.Upper urinary tract stones of the outpatients removed by extracorporeal shock wave lithotripsy,and those of the inpatients removed by surgery were collected for quantitative and qualitative constituent analyses by geographical region using infrared spectrometry.Results Upper urinary tract stones were more often found in those 30 to 70 years old,with a male to female ratio about 1.75∶1.Kidney stones and ureteral stones accounted for similar proportions(about 1.1∶1),and the mixed stones were more common(61.5%).Calcium-containing stones were the major type of upper urinary tract stones in participants from each geographic regions,with calcium oxalate monohydrate being the most.The prevalence of infectious stones showed no significant differences across participants from three regions(P>0.05).The prevalence of uric acid-containing stones in participants from plain was significantly different from that of participants from mountainous or coastal region(P<0.05).Conclusion Calcium-containing stones were the most common prevalent in upper urinary tract stones patients across three geographic regions of Hebei,and the prevalence of uric acid-containing s

关 键 词：尿路结石 结石成分 地理位置 河北 

分 类 号：R691.4[医药卫生—泌尿科学]