桂甘龙牡汤治疗室性早搏疗效及安全性的Meta分析  

Efficacy and Safety of Guigan Longmu Decoction For Premature Ventricular Contraction:A Meta-analysis

作　　者：张文杰 吴晓博 谭雨晴 李军[1] 查玉玲 ZHANG Wenjie;WU Xiaobo;TAN Yuqing;LI Jun;ZHA Yuling(Guang′anmen Hospital,China Academy of Chinese Medicine Science,Beijing 100053,China;Beijing University of Chinese Medicine,Beijing 100029,China)

机构地区：[1]中国中医科学院广安门医院,北京100053 [2]北京中医药大学,北京100029

出　　处：《世界中医药》2021年第22期3348-3354,共7页World Chinese Medicine

基　　金：国家自然科学基金面上项目(81973836);国家中医药管理局国家中医临床研究基地业务建设科研专项课题(JDZX2015249)。

摘　　要：目的:系统评价桂甘龙牡汤治疗室性早搏的疗效及安全性。方法:检索中国期刊全文数据库、中国学术期刊数据库、中文科技期刊数据库、Cochrane Library、Pubmed、SinoMed、EMbase共7个数据库,搜集有关桂甘龙牡汤治疗室性早搏的随机对照试验(RCT),检索时间限定为建库至2020年3月。由2名研究人员独立参与文献筛选、提取资料和风险评估过程,然后使用Revman 5.3软件进行Meta分析。结果:纳入18个RCT共1377例患者。Meta分析结果显示:有效率RR=1.26,95%CI为1.18~1.34,P<0.00001;临床症状疗效:RR=1.23,95%CI为1.14~1.33,P<0.00001;动态心电图:MD=-424.99,95%CI为-640.98~-209.00),P=0.0001;中医症状疗效:MD=-4.45,95%CI为-5.83~-3.07),P<0.00001;不良反应:RR=0.39,95%CI为0.23~0.67),P=0.0007。结论:桂甘龙牡汤治疗室性早搏的疗效优于对照组,疗效及安全性兼具。受纳入研究的数量与质量限制,需要扩大样本量,开展更为严格的随机对照、多中心、双盲、前瞻性临床试验,为临床实践提供更多证据。Objective:To systematically review the efficacy and safety of Guigan Longmu Decoction in the treatment of premature ventricular contraction(PVC).Methods:CNKI,Cochrane Library,WanFang Data,Pubmed、SinoMed,EMbase,VIP databases were searched to collect randomized controlled trials(RCTs)about the treatment of PVC from inception to March,2020.A total of 2 researchers independently participated in the process of literature screening,data extraction and risk assessment,and then used Revman 5.3 for meta-analysis.Results:A total of 18 RCTs involving 1377 patients were included.The results of meta-analysis showed that,the effect rate RR=1.26,95%CI 1.18 to 1.34,P<0.00001;curative effect on symptoms RR=1.23,95%CI 1.14 to 1.33,P<0.00001;improve effect on dynamic electrocardiogram(DCG)MD=-424.99,95%CI-640.98 to-209.00,P=0.0001;curative effect on TCM symptoms MD=-4.45,95%CI-5.83 to-3.07,P<0.00001;rate of adverse reactions RR=0.39,95%CI 0.23 to 0.67,P=0.0007.Conclusion:Guigan Longmu Decoction has more significant curative effect than control group,both with efficacy and safety.The quantity and quality of this study limited conducts more large sample RCT with rigorous control,multicenter,random,double blind and prospect to provide more evidence for clinical support.

关 键 词：桂甘龙牡汤 室性早搏 心阳不振 META分析 系统评价 随机对照试验 疗效 安全性 

分 类 号：R289.5[医药卫生—方剂学] R541[医药卫生—中药学]