人参固本口服液治疗放化疗骨髓抑制机制探讨  

Study on Mechanism of Renshen Guben Oral Liquid in Treatment of Bone Marrow Suppression Caused by Radiotherapy and Chemotherapy

作　　者：谭峰[1] 管华全[1] 樊巧玲[1] TAN Feng;GUAN Huaquan;FAN Qiaoling(School of Integrated Chinese and Western Medicine,Nanjing University of Chinese Medicine,Nanjing 210023,China)

机构地区：[1]南京中医药大学中西医结合学院,南京210023

出　　处：《世界中医药》2021年第22期3363-3366,共4页World Chinese Medicine

基　　金：国家自然科学基金面上项目(81573874,81873229);江苏省高校优势学科建设工程资助项目(中西医结合)。

摘　　要：骨髓抑制是恶性肿瘤放化疗中的常见不良反应之一。中医药在治疗放化疗所致的骨髓抑制中具有效果明确、不良反应小的优点。人参固本口服液由千古名方六味地黄丸与人参固本丸合方而成,是治疗放化疗骨髓抑制的有效药物。现从人参固本口服液的组方结构、功效特点和现代药理研究探究其治疗放化疗骨髓抑制的机制,以期为人参固本口服液在放化疗骨髓抑制防治中的应用提供理论指导。Bone marrow suppression is one of the commonest side effects in chemoradiotherapy for malignant tumors.Traditional Chinese medicine has the advantages of clear effect and small adverse reaction in the treatment of myelosuppression caused by radiotherapy and chemotherapy.Renshen Guben Oral Liquid is a combination of classic prescriptions,Liuwei Dihuang Pills and Renshen Guben Pills.It is an effective prescription for treating bone marrow suppression caused by radiotherapy and chemotherapy.This study explores the mechanism of the treatment of myelosuppression caused by radiotherapy and chemotherapy from the formulation structure,efficacy characteristics and modern pharmacological studies ofRenshen Guben Oral Liquid to provide theoretical guidance for the application of it in the prevention and treatment of bone marrow suppression caused by radiotherapy and chemotherapy.

关 键 词：人参固本口服液 放化疗 骨髓抑制 组方结构 人参固本丸 六味地黄丸 补肾 机制 

分 类 号：R289.5[医药卫生—方剂学]