中国四川地区妊娠妇女特异性促甲状腺激素参考值范围的建立  

Establishment of reference interval of specific thyroid-stimulating hormone in pregnant women in Sichuan Province of China

作　　者：郭英 魏彬[2] 戴维[1] 王霞[1] 蒋冬梅[1] 李莹莹[1] 陈平[1] GUO Ying;WEI Bin;DAI Wei;WANG Xia;JIANG Dongmei;LI Yingying;CHEN Ping(Department of Laboratory Medicine,West China Second University Hospital of Sichuan University,Key Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University),Ministry of Education,Chengdu 610041,China;不详)

机构地区：[1]四川大学华西第二医院检验科,出生缺陷与相关妇儿疾病教育部重点实验室,成都610041 [2]四川大学华西医院实验医学科,成都610041

出　　处：《实用医学杂志》2021年第22期2919-2922,共4页The Journal of Practical Medicine

基　　金：四川大学华西第二医院新芽基金(编号:KX189)。

摘　　要：目的探讨中国四川地区妊娠期妇女特异性促甲状腺激素的参考值范围。方法收集2015年1月1日至2020年12月30日期间四川大学华西第二医院产科或妇科门诊就诊孕妇的促甲状腺激素(thyroid stimulating hormone,TSH)检测结果。根据甲状腺过氧化物酶抗体(thyroid peroxidase antibodies,TPOAb)是否阳性分组,建立参考值范围,所有过程均参照临床实验室标准协会文件CLSI EP28-A3。结果共纳入符合标准的TPOAb阴性组孕妇14 332例,TPOAb阳性组孕妇10 254例。两组孕妇均孕早期TSH中位数水平最低,孕晚期最高,孕中期处于两者之间,趋势一致。本研究建立的孕早期、孕中期和孕晚期TPOAb阴性组TSH参考值范围分别为0.02~5.23、0.03~5.24、0.37~5.68 mIU/L;TPOAb阳性组TSH参考值范围分别为0.23~4.73、0.35~4.67、0.43~4.75 mIU/L。结论建立特异性妊娠早、中、晚期血清TSH参考区间非常必要,TPOAb阳性与阴性孕妇TSH参考值范围不同,应全程监测甲状腺激素变化。Objective To investigate the normal reference interval of specific thyroid-stimulating hormone(TSH)in women during pregnancy in Sichuan province of China. Methods TSH test results were collected in pregnant women in obstetrics or gynecology outpatient clinic of the Second West China Hospital of Sichuan University between January 1,2015,and December 30,2020. Reference intervals were established according to whether the thyroid peroxidase antibodies(TPOAb)was positive or not and all procedures were conducted based on the document CLSI EP28-A3 by the Clinical Laboratory Standards Institute. Results A total of 14,332 pregnant women in the TPOAb-negative group and 10,254 pregnant women in the TPOAb-positive group who met the criteria were included. The median TSH levels were lowest in early pregnancy,highest in late pregnancy,and in between in midpregnancy in both groups,with consistent trends. According to the CLSI EP28-A3 document,we established the reference intervals of TSH in early,mid and late pregnancy for the TPOAb-negative group were 0.02 ~ 5.23 mIU/L,0.03 ~ 5.24 mIU/L and 0.37 ~ 5.68 mIU/L,respectively;for the TPOAb-positive group were 0.23 ~ 4.73 mIU/L,0.35 ~ 4.67 mIU/L,0.43 ~ 4.75 mIU/L,respectively. Conclusions It is essential to establish specific reference intervals for serum TSH during pregnancy,and thyroid hormone changes should be monitored throughout pregnancy in TPOAb-positive women.

关 键 词：妊娠 参考值范围 促甲状腺激素 甲状腺过氧化物酶抗体 

分 类 号：R446.1[医药卫生—诊断学]