SPOCK2基因多态性与早产儿支气管肺发育不良易感性的关系  

Relationship between SPOCK2 gene polymorphism and susceptibility to bronchopulmonary dysplasia in preterm infants

作　　者：庞欢欢 任俊梅[1] 范晓莉 PANG Huanhuan;REN Junmei;FAN Xiaoli(Department of Pediatrics,Lvliang People′s Hospital,Lvliang 033000,China)

机构地区：[1]吕梁市人民医院儿科,山西吕梁033000

出　　处：《山东医药》2021年第34期29-32,共4页Shandong Medical Journal

基　　金：山西省卫生健康科研课题(20180115)。

摘　　要：目的 探讨现富含半胱氨酸的酸性分泌蛋白(骨结合蛋白)、cwcv和kazal样蛋白聚糖2(SPOCK2)基因多态性与早产儿支气管肺发育不良(BPD)易感性的关系。方法 选取102例BPD早产儿为BPD组,根据1∶1比例选择同期新生儿重症监护室收治的102例无肺疾病的早产儿为对照组。Mass ARRAY平台i PLEX质谱阵列法检测SPOCK2基因rs1049269、rs1245560位点单核苷酸多态性。比较两组早产儿SPOCK2基因rs1049269、rs1245560位点基因型频率和等位基因频率。结果 与对照组相比,BPD组孕周缩短,出生体质量、出生5 min后Apgar评分降低,机械通气时间、氧疗时间、住院时间延长(P均<0.05)。BPD组rs1049269位点AA基因型频率低于对照组,AG基因型频率和G等位基因频率高于对照组(P均<0.05)。两组早产儿SPOCK2基因rs1245560位点基因型频率和等位基因频率比较差异无统计学意义(P均> 0.05)。结论 SPOCK2基因rs1049269位点单核苷酸多态性与BPD易感性相关。Objective To investigate the relationship between secreted protein acidic and rich in cysteine(bone binding protein),cwcv and kazal-like domains proteoglycan 2(SPOCK2)gene polymorphisms and the susceptibility to bronchopulmonary dysplasia(BPD)in preterm infants.MethodsTotally 102 preterm infants with BPD were selected as BPD group,and 102 preterm infants without lung disease treated in neonatal intensive care unit in the same period were selected as the control group according to the ratio of 1∶1.The single nucleotide polymorphisms of SPOCK2 gene rs1049269 and rs1245560 were detected by Mass ARRAY platform iPLEX mass spectrometry array.The genotype frequencies and allele frequencies of SPOCK2 gene rs1049269 and rs1245560 were compared between the two groups.ResultsCompared with the control group,the gestational weeks were shortened,the birth body mass and Apgar score 5 minutes after birth were reduced,and the time of mechanical ventilation,oxygen therapy and hospitalization were prolonged in the BPD group(all P<0.05).The frequencies of AA genotype at rs1049269 locus in the BPD group were lower than those in the control group,and the frequencies of AG genotype and G allele were higher than those in the control group(all P<0.05).There were no significant differences in the genotype frequency and allele frequency of SPOCK2 gene rs1245560 between the two groups(all P>0.05).Conclusion The single nucleotide polymorphism at rs1049269 of SPOCK2 gene is associated with susceptibility to BPD.

关 键 词：支气管肺发育不良 富含半胱氨酸的酸性分泌蛋白 cwcv和kazal样蛋白聚糖2 

分 类 号：R722[医药卫生—儿科]