颞下颌关节紊乱病疼痛的脑结构磁共振分析和中枢机制研究  

MRI analysis and central mechanism of temporo mandibular disorders pain

作　　者：唐小娟 熊妍希 郗磊 TANG Xiaojuan;XIONG Yanxi;XI Lei(Department of Radiology,Shiyan People′s Hospital,Hubei University of Medicine,Shiyan 442000,China;不详)

机构地区：[1]十堰市人民医院(湖北医药学院附属人民医院)放射影像中心,湖北十堰442000 [2]十堰市人民医院(湖北医药学院附属人民医院)麻醉科,湖北十堰442000

出　　处：《实用医学杂志》2021年第21期2757-2763,共7页The Journal of Practical Medicine

摘　　要：目的分析颞下颌关节紊乱病(temporo-mandibular disorders,TMD)在磁共振检查下的脑结构和中枢机制。方法回顾性分析12例TMD患者组成TMD组,选取和TMD患者年龄匹配的12名健康人群组成健康组。两组患者完成自评量表,TMD患者接受视觉模拟评分,所有受试者均接受脑部磁共振检查,分析两组受试者的脑区局部一致性和功能连接,以此分析TMD疼痛和脑部中枢机制的相关性。结果受试者的局部一致性分析显示,健康组组内比较,开口状态下的ReHo值高于闭口状态下的值,差异具有统计学意义(P <0.05),两组在开口状态下比较ReHo值差异具有统计学意义(P <0.05)。功能连接分析显示,TMD组两种功能连接均低于健康组,差异具有统计学意义(P <0.05),并且和疼痛强度具有相关性。结论 TMD相关疼痛和重要脑区异常的局部活动一致性相关,同时也和相关脑区之间的功能连接异常有关,此外造成相关脑区出现异常的主要原因为心理因素。Objective To analyze the brain structure and central mechanism of temporo mandibular disorders(TMD)under MRI examination. Methods 12 patients with TMD were selected as TMD group,and 12 healthy people matched with TMD patients were selected as healthy group.Two groups of patients completed the self rating scale,TMD patients received visual analog score,all subjects received brain magnetic resonance examination,analysis of the two groups of patients with brain regional consistency and functional connectivity,in order to analyze the correlation between TMD pain and brain central mechanism. Results The local consistency analysis showed that the ReHo value in the open state was higher than that in the closed state,and the difference was statistically significant(P < 0.05),the ReHo value of the two groups in the open state was statistically significant(P < 0.05). Functional connectivity analysis showed that the two functional connectivity of TMD group were lower than that of healthy group,the difference was statistically significant(P < 0.05),And it is related to the intensity of pain. Conclusion TMD related pain is related to the local activity consistency of important brain regions,and also related to the abnormal functional connection between the related brain regions. In addition,the main reason for the abnormality of the related brain regions is psychological factors.

关 键 词：颞下颌关节紊乱病 磁共振 中枢机制 局部一致性 功能连接 

分 类 号：R445.2[医药卫生—影像医学与核医学]