江苏地区14岁以下儿童幽门螺杆菌感染现状及对生长发育的影响和相关因素分析  

The influence of Helicobacter pylori infection on the growth and development of children under 14 years old in Jiangsu Province

作　　者：朱丹荣[1] 薛娟[1] 董娜[1] 徐伟[1] 钱娟[1] 孔婷[1] 潘紫云 盛伟松[1] ZHU Danrong;XUE Juan;DONG Na;XU Wei;QIAN Juan;KONG Ting;PAN Ziyun;SHENG Weisong(Department of Children’s Gastrointestinal Endoscopy,the Second Affiliated Hospital of Nanjing Medical University,Nanjing 210000,China)

机构地区：[1]南京医科大学第二附属医院儿童消化内镜中心,江苏南京210000

出　　处：《胃肠病学和肝病学杂志》2021年第12期1367-1371,共5页Chinese Journal of Gastroenterology and Hepatology

基　　金：江苏省妇幼健康科研项目(F201638)。

摘　　要：目的分析江苏地区14岁以下儿童幽门螺杆菌(Helicobacter pylori,H.pylori)感染现状及对生长发育的影响和相关影响因素。方法随机选取江苏省内南京、苏州、徐州、南通、盐城等地的3~14岁儿童500例,利用;C呼气试验采集标本,对所有儿童的身高、体质量、头围、胸围及臀围进行测量,分析H.pylori感染现状及其对儿童生长发育的影响,并通过现场调查问卷和电话向儿童父母询问相结合的方式调查对H.pylori感染可能有影响的多个因素,并筛选导致儿童H.pylori感染的独立危险因素。结果 500例入组儿童共检出H.pylori感染者168例,H.pylori感染率为33.60%。不同性别及居住地的儿童H.pylori感染率相比,差异无统计学意义(P>0.05),而不同年龄段的儿童H.pylori感染率,差异有统计学意义(P<0.05);H.pylori感染组儿童的身高、体质量及胸围均低于健康对照组,差异有统计学意义(P<0.05),而两组头围及臀围相比,差异无统计学意义(P>0.05);通过分析发现,儿童H.pylori感染与父母受教育程度、家庭年收入、父亲吸烟与饮酒、父母饭前便后洗手、父母胃病史、独立餐具、喜食零食、饭前饮水、吸吮手指有关,差异有统计学意义(P<0.05),而家庭成员数与儿童H.pylori感染无关,差异无统计学意义(P>0.05);将单因素分析得出的10个影响因素进行多因素Logistic回归分析,父母受教育程度为专科及以下(OR=1.912,P<0.001)、家庭成员胃病史(OR=2.403,P=0.028)、喜食零食(OR=1.411,P<0.001)、吸吮手指(OR=2.203,P=0.011)、无独立餐具(OR=0.544,P=0.002)是影响儿童H.pylori感染的独立危险因素,差异有统计学意义(P<0.05)。结论 H.pylori感染会导致儿童生长发育低于正常人群,且H.pylori感染与父母受教育程度、家庭成员胃病史、喜食零食、吸吮手指习惯、有无独立餐具密切相关,实行独立餐具制度、教育儿童注意手-口卫生、改善家庭成员卫生防病意识等可有�Objective To analyze the influence of Helicobacter pylori(H.pylori) infection on the growth and development of children under 14 years old in Jiangsu Province.Methods A total of 500 cases of 3-14 years old children in Nanjing, Suzhou, Xuzhou, Nantong and Yancheng of Jiangsu Province were randomly selected. The height, weight, head circumference, chest circumference and hip circumference of all children were measured by;C breath test, and the influence of H.pylori infection on children’s growth and development and its infection status were analyzed. The combination of on-site questionnaire and telephone was used to ask the parents of the children. The risk factors of H.pylori infection in children were screened by statistical software.Results A total of 168 cases of H.pylori infection were detected in 500 children, and the H.pylori infection rate was 33.60%. There was no significant difference in H.pylori infection rate between children of different gender and residence(P>0.05), but there was significant difference in H.pylori infection rate between children of different age groups(P<0.05);the height, weight and chest circumference of children in H.pylori infection group were lower than those in healthy control group, and the difference was statistically significant(P<0.05), but there was no significant difference in head circumference and hip circumference between the two groups(P>0.05);through the analysis, it was found that children’s H.pylori infection was related to their parents’ education level, family annual income, father’s smoking and drinking, parents’ washing hands before and after meals, parents’ history of stomach disease, independent tableware, like snacks, drinking water before meals, sucking fingers, the difference was statistically significant(P<0.05), but the number of family members was not related to children’s H.pylori infection, the difference was not statistically significant(P>0.05);the 10 influencing factors obtained from single factor analysis were analyzed by multi factor

关 键 词：儿童 幽门螺旋杆菌 生长发育 相关因素 

分 类 号：R378[医药卫生—病原生物学]