基于O-环己二烯酮型1,6-烯炔合成氢化苯并呋喃的反应研究进展  

Progress in the Synthesis of Hydrobenzofurans from O-Cyclohexadienone-tethered 1,6-Enynes

作　　者：李志清 邱潇杨 孟楠 柳竹青 Li Zhiqing;Qiu Xiaoyang;Meng Nan;Liu Zhuqing(Advanced Research Institute for Multidisciplinary Science,Qilu University of Technology,Jinan 250353;Shandong Weifang Rainbow Chemical Co.Ltd.,Weifang,Shandong 250101)

机构地区：[1]齐鲁工业大学前沿交叉学科研究院,济南250353 [2]山东潍坊润丰化工股份有限公司,山东潍坊250101

出　　处：《有机化学》2021年第11期4306-4319,共14页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.22001140);山东省自然科学基金(No.ZR2020QB002)资助项目.

摘　　要：氢化苯并呋喃骨架广泛存在于生物活性分子、天然产物和药物分子中,过渡金属催化的O-环己二烯酮型1,6-烯炔经分子内或分子间C—H键官能团化/环化串联反应是构建这类骨架较为经济、有效的方法.总结了过渡金属催化O-环己二烯酮型1,6-烯炔经C—H键官能团化/环化串联反应合成氢化苯并呋喃类化合物反应的研究进展,主要介绍了各类过渡金属催化的反应类型、反应机理和手性控制中配体的选择,并对该领域所面临的挑战和发展前景进行了展望与探讨.Hydrobenzofurans are abundant in bioactive molecules,natural products and drug molecules.Transition-metalcatalyzed intramolecular or intermolecular C—H bond functionalization/cyclization cascade of O-linkered cyclohexadienone-tethered 1,6-enynes is an economic and efficient way to construct this skeleton.The progress in the synthesis of hydrobenzofurans from cyclohexadienone-tethered 1,6-enynes via C—H bond functionalization/cyclization cascade catalyzed by different transition-metals is discussed.The relevant reaction modes,mechanisms and the selection of ligands for chiral control are mainly introduced.Finally,the challenges and development prospects in this field are also prospected and discussed.

关 键 词：O-环己二烯酮型1 6-烯炔 环化反应 C—H键官能团化 氢化苯并呋喃 

分 类 号：O626.11[理学—有机化学]