慢性肾病患者肾功能与主动脉僵硬度超声评价指标的相关性  

Correlation between renal function and aortic stiffness index assessed by Doppler ultrasound in patients with chronic kidney disease

作　　者：樊文莉 梁潇 杜京奚 王鹏 杨勇 Fan Wenli;Liang Xiao;Du Jingxi;Wang Peng;Yang Yong(Department of Ultrasound Medicine,Weibei Central Hospital,Shanxi Health Medical Group,Weinan 715100,China;Department of UltrasoundMedicine,Tangdu Hospital of AirforceMilitaryMedical University,Xi'an 710038,China)

机构地区：[1]陕西健康医疗集团渭北中心医院超声科,陕西渭南715100 [2]空军军医大学唐都医院超声医学科,西安710038

出　　处：《中华医学超声杂志（电子版）》2021年第11期1084-1089,共6页Chinese Journal of Medical Ultrasound(Electronic Edition)

基　　金：空军军医大学第二附属医院临床研究项目资助(2021LCYJ030);第四军医大学唐都医院科技创新发展基金资助(2017LCYJ009)。

摘　　要：目的探讨慢性肾病(CKD)患者肾功能与主动脉僵硬度之间的相关性及影响因素。方法纳入2021年1月至2021年5月空军军医大学唐都医院临床诊断为CKD的患者117例,以肾小球滤过率(GFR)为依据分为G1~5期,采用超声多普勒测量所有受试者的颈-股动脉脉搏波传播速度(PWV)。采用Pearson相关分析GFR与PWV之间的相关性,采用多因素线性回归,纳入并校正各混杂因素分析GFR的独立影响因素。结果117例CKD患者GFR值为(59.8±32.0)ml/(min·1.73 m^(2)),颈-股动脉PWV测值为(8.83±1.81)m/s,GFR与颈-股动脉PWV间存在中等强度的负相关关系(r=-0.5698,P<0.001)。校正混杂因素后,颈-股动脉PWV是GFR的独立影响因素(P<0.001)。颈-股动脉PWV每增加1 m/s,GFR降低6.035个单位。结论CKD患者的肾功能指标GFR与颈-股动脉PWV之间存在独立相关关系,提示主动脉僵硬度增加与CKD的发生发展关系密切。Objective To explore the association between renal function and aortic stiffness and its influencing factors in patients with chronic kidney disease(CKD).Methods A total of 117 CKD patients at Tangdu Hospital,Air Force Military Medical University from January to May 2021 were included in this study.According to the glomerular filtration rate(GFR),the CKD in the subjects were divided into G1-5 stages.The carotid-femoral pulse wave velocity(PWV)of all subjects was measured by Doppler ultrasound.Pearson analysis was used to analyze the correlation between GFR and PWV,and multi-factor linear regression was adopted to include and correct confounding factors to analyze the independent influencing factors for GFR.Results In the 117 CKD patients,the mean GFR was 59.8±32.0 ml/(min•1.73 m^(2)),and the carotid-femoral PWV was(8.83±1.81)m/s.There was a moderate inverse correlation between GFR and carotid-femoral PWV(r=-0.5698,P<0.001).After adjustment for confounding factors,there was an independent correlation between carotid-femoral PWV and GFR(P<0.001).Conclusion This study demonstrated that there is an independent correlation between renal function and carotid-femoral PWV in patients with CKD,suggesting that increased aortic stiffness is closely related with CKD.

关 键 词：慢性肾病 动脉僵硬度 脉搏波传播速度 超声检查 多普勒 肾小球滤过率 

分 类 号：R445.1[医药卫生—影像医学与核医学] R692[医药卫生—诊断学] R543.1[医药卫生—临床医学]