NCPAP联合硫酸镁持续静脉滴注治疗婴儿期重症毛细支气管炎患儿的疗效评价  

Evaluation of the curative effect of NCPAP combined with continuous intravenous infusion of magnesium sulfate in the treatment of infants with severe bronchiolitis

作　　者：张园园 ZHANG Yuanyuan(PICU,Xihua People's Hospital,Zhoukou Henan 466600,China)

机构地区：[1]西华县人民医院PICU,河南周口466600

出　　处：《临床研究》2021年第12期73-76,共4页Clinical Research

摘　　要：目的探究经鼻持续气道正压通气(NCPAP)联合硫酸镁持续静脉滴注治疗婴儿期重症毛细支气管炎患儿的效果。方法回顾性选取西华县人民医院76例婴儿期重症毛细支气管炎患儿(2018年1月至2020年1月),将接受硫酸镁治疗的38例患儿列为硫酸镁组,将接受NCPAP联合硫酸镁治疗的38例患儿列为联合组。对比两组疗效、临床症状消失时间[湿啰音、发热、咳嗽、憋喘消失时间]、住院时间、治疗前后血气指标[动脉血氧分压(PaO_(2))、二氧化碳分压(PaCO_(2))、PaO_(2)/FiO_(2)]水平、病情相关指标(心率、呼吸频率)和不良反应发生率。结果联合组总有效率94.74%(36/38)高于硫酸镁组73.68%(28/38)(P<0.05);联合组湿啰音、发热、咳嗽、憋喘等临床症状消失时间、住院时间较硫酸镁组短(P<0.05);联合组治疗7 d后PaO_(2)/FiO_(2)、PaO_(2)水平较硫酸镁组高,PaCO_(2)水平较硫酸镁组低(P<0.05);联合组治疗后心率、呼吸频率低于常规组(P<0.05);两组不良反应发生率对比,无明显差异(P>0.05)。结论NCPAP联合硫酸镁持续静脉滴注治疗婴儿期重症毛细支气管炎患儿效果显著,可有效促进临床症状缓解,降低心率及呼吸频率,改善血气指标,安全性高。Objective To explore the effect of nasal continuous positive airway pressure(NCPAP)combined with continuous intravenous infusion of magnesium sulfate in the treatment of infants with severe bronchiolitis.Methods 76 children with severe infantile bronchiolitis in our hospital were selected retrospectively(January 2018 to January 2020),38 children who received magnesium sulfate treatment were classified as magnesium sulfate group,and they will receive NCPAP combined with magnesium sulfate The 38 children treated were classified as the combined group.Compare the efficacy of the two groups,the disappearance time of clinical symptoms[the disappearance time of rales,fever,cough,and breathlessness],hospitalization time,blood gas indicators before and after treatment[arterial blood oxygen partial pressure(PaO_(2)),carbon dioxide partial pressure(PaCO_(2)),PaO_(2)/FiO_(2)]level,disease-related indicators(heart rate,respiratory rate),incidence of adverse reactions.Results The total effective rate of the combined group was 94.74%(36/38)higher than that of the magnesium sulfate group 73.68%(28/38)(P<0.05);The clinical symptoms such as rales,fever,cough,and wheezing in the combined group disappeared and the hospital stay was shorter than that in the magnesium sulfate group(P<0.05);After 7 days of treatment in the combined group,PaO_(2)/FiO_(2) and PaO_(2) levels were higher than those in the magnesium sulfate group,and PaCO_(2) levels were lower than those in the magnesium sulfate group(P<0.05);After treatment,the heart rate and respiratory frequency of the combined group were lower than those of the conventional group(P<0.05);there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion NCPAP combined with continuous intravenous infusion of magnesium sulfate is effective in treating infants with severe bronchiolitis.It can effectively promote the relief of clinical symptoms,reduce heart rate and respiratory frequency,improve blood gas indicators,and has high safety.

关 键 词：经鼻持续气道正压通气 硫酸镁 毛细支气管炎 

分 类 号：R562.21[医药卫生—呼吸系统]