参芪健胃颗粒对脾胃病湿热证患者胃肠激素及氧化应激的影响  

Effects of Shenqi Jianwei Granules on Gastrointestinal Hormones and Oxidative Stress in Patients with Spleen and Stomach Disease with Damp-heat Syndrome

作　　者：李懿放 LI Yifang(Shenyang Hospital of Traditional Chinese Medicine,Shenyang 110003,China)

机构地区：[1]沈阳市中医院,辽宁沈阳110003

出　　处：《中国医学创新》2021年第33期95-99,共5页Medical Innovation of China

摘　　要：目的:探讨参芪健胃颗粒对脾胃病湿热证患者胃肠激素及氧化应激的影响。方法:选取2017年2月-2020年10月于沈阳市中医院诊治的128例脾胃病湿热证患者,根据随机抽签原则将其分为中药组与对照组,每组64例。对照组给予奥美拉唑结合克拉霉素治疗,中药组在对照组治疗的基础上给予参芪健胃颗粒治疗。比较两组疗效、症状改善情况及治疗前后的胃肠激素[胃泌素(GAS)、胃动素(MTL)]和氧化应激指标[超氧化物歧化酶(SOD)、丙二醛(MDA)]。结果:中药组总有效率为90.6%,高于对照组的75.0%,差异有统计学意义(P<0.05)。中药组胃内嘈杂、胃部胀痛、无食欲、反酸胃灼热改善率均高于对照组,差异均有统计学意义(P<0.05)。治疗前,两组GAS、MTL比较,差异均无统计学意义(P>0.05);治疗后,两组GAS、MTL均高于治疗前,且中药组均高于对照组,差异均有统计学意义(P<0.05)。治疗前,两组SOD、MDA比较,差异均无统计学意义(P>0.05);治疗后,两组MDA均低于治疗前,SOD均高于治疗前,且中药组MDA低于对照组,SOD高于对照组,差异均有统计学意义(P<0.05)。结论:对脾胃病湿热证患者应用参芪健胃颗粒能促进胃肠激素的分泌,改善氧化应激状况,从而促进临床症状缓解,提高治疗效果。Objective:To investigate the effects of Shenqi Jianwei Granules on gastrointestinal hormones and oxidative stress in patients with spleen and stomach disease with damp-heat syndrome.Method:A total of 128 patients with spleen and stomach disease with damp-heat syndrome treated in Shenyang Hospital of Traditional Chinese Medicine from February 2017 to October 2020 were selected,they were randomly divided into traditional traditional Chinese medicine group and control group according to the principle of random drawing,64 cases in each group.The control group was treated with Omeprazole combined with Clarithromycin,and the traditional Chinese medicine group was treated with Shenqi Jianwei Granules on the basis of the control group.The efficacy,symptom improvement were compared between two groups,and gastrointestinal hormones[gastrin(GAS),motilin(MTL)]and oxidative stress indexes[superoxide dismutase(SOD),malondialdehyde(MDA)]before and after treatment were compared between two groups.Result:The total effective rate of the traditional Chinese medicine group was 90.6%,which was higher than 75.0%of the control group,the difference was statistically significant(P<0.05).The improvement rate of intragastric noise,distension,anorexia,acid reflux and heartburn in the traditional Chinese medicine group were higher than those of the control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in GAS and MTL between two groups(P>0.05);after treatment,GAS and MTL of both groups were higher than those before treatment,those of the traditional Chinese medicine group were higher than those of the control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in SOD and MDA between two groups(P>0.05);after treatment,MDA of both groups were lower than those before treatment,SOD of both groups were higher than those before treatment,MDA of the traditional Chinese medicine group was lower than that of the control

关 键 词：参芪健胃颗粒 脾胃病湿热证 胃肠激素 氧化应激 超氧化物歧化酶 

分 类 号：R256.3[医药卫生—中医内科学]