胎儿生长受限影响因素及妊娠结局分析  

Analysis of factors affecting fetal growth restriction and pregnancy outcome

作　　者：吴小雅 陈宇清[1] WU Xiaoya;CHEN Yuqing(Department of Obstetrics and Gynecology,Fujian Provincial Hospital,Fujian,Fuzhou 350001,China)

机构地区：[1]福建省立医院妇产科,福建福州350001

出　　处：《中国医药科学》2021年第21期138-141,共4页China Medicine And Pharmacy

摘　　要：目的分析235例胎儿生长受限(FGR)发生的影响因素及妊娠结局。方法选取2015年1月1日至2020年12月31日福建省立医院产科收治的235例胎儿生长受限孕产妇为FGR组,同期新生儿出生体重正常孕产妇300例为非FGR组,比较两组孕产妇妊娠相关资料及妊娠结局,多因素logistic回归分析发生FGR的影响因素。结果FGR组中高龄、自然流产≥2次、妊娠期高血压疾病、妊娠期肝内胆汁淤积、低蛋白血症、自身免疫性疾病、妊娠期糖尿病、肝功能异常、子宫异常(纵隔子宫、子宫肌瘤、子宫腺肌症)、脐带异常(脐带扭转、脐带过短、脐带绕颈)、羊水过少的发生率均高于非FGR组,差异有统计学意义(P<0.05)。FGR组早产、胎儿窘迫发生率明显高于非FGR组,其住院天数延长,住院费用明显增加,分娩方式上看,FGR组剖宫产率增加,差异均有统计学意义(P<0.05)。多因素logistic回归分析结果显示,妊娠期高血压疾病、重度子痫前期、自然流产≥2次、子宫异常、脐带异常、羊水过少为发生FGR独立危险因素(P<0.05)。结论FGR的发病涉及多病因、多因素,积极防治妊娠期合并症及并发症,能够改善FGR妊娠结局。Objective To analyze the factors affecting the occurrence of fetal growth restriction(FGR)and pregnancy outcome in 235 pregnant and puerperal women.Methods A total of 235 pregnant and puerperal women with FGR admitted to the Department of Obstetrics and Gynecology in Fujian Provincial Hospital from January 1,2015 to December 31,2020 were selected as the FGR group,and 300 puerperal women with normal birth weight during the same period were selected as the non-FGR group.The pregnancy-related data and pregnancy outcome were compared between the two groups of pregnant and puerperal women,and the factors affecting the occurrence of FGR were analyzed by multivariate logistic regression analysis.Results The number of pregnant women with advanced age,the incidences of spontaneous abortion≥2 times,hypertensive disorders in pregnancy,intrahepatic cholestasis in pregnancy,hypoproteinemia,autoimmune diseases,gestational diabetes mellitus,hepatic dysfunction,uterine abnormalities(septate uterus,uterine fibroids,adenomyosis),umbilical cord abnormalities(umbilical cord torsion,excessively short cord,umbilical cord around the neck),and oligohydramnios were all higher in the FGR group than those in the non-FGR group,with statistically significant differences(P<0.05).The incidences of preterm delivery and fetal distress in the FGR group were significantly higher than those in the non-FGR group,and the number of hospitalization days and hospitalization costs in the FGR group were significantly more than those in the non-FGR group.Meanwhile,in terms of the delivery methods,the rate of cesarean section in the FGR group was higher than that in the non-FGR group,with statistically significant difference(P<0.05).The multivariate logistic regression analysis showed that hypertensive disorders in pregnancy,severe preeclampsia,spontaneous abortion≥2 times,uterine abnormalities,umbilical cord abnormalities,and oligohydramnios were independent risk factors for the development of FGR(P<0.05).Conclusion The occurrence of FGR involves multi

关 键 词：胎儿生长受限 妊娠期高血压疾病 影响因素 妊娠结局 

分 类 号：R714.5[医药卫生—妇产科学]