加速器直接生产^(99m)Tc的化学分离纯化研究现状  

Current Status of Chemical Separation and Purification for Direct Production of ^(99m)Tc on Cyclotron Accelerator

作　　者：范芳丽[1,3] 程念炜 吴晓蕾 秦芝[1,3] FAN Fangli;CHENG Nianwei;WU Xiaolei;QIN Zhi(Institute of Modern Physics,Chinese Academy of Sciences,Lanzhou 730000,China;School of Nuclear Science and Technology,Lanzhou University,Lanzhou 730000,China;Advanced Energy Science and Technology Guangdong Laboratory,Huizhou 516000,China)

机构地区：[1]中国科学院近代物理研究所,兰州730000 [2]兰州大学核科学与技术学院,兰州730000 [3]先进能源科学与技术广东省实验室,惠州516000

出　　处：《同位素》2021年第6期556-564,共9页Journal of Isotopes

基　　金：甘肃省引导科技创新发展专项资金项目(基于强流超导直线加速器的医用同位素研发)。

摘　　要：^(99m)Tc(T_(1/2)=6.01 h)是^(99)Mo的衰变子体,是目前核医学临床诊断应用最为广泛的放射性核素,其使用量约占所有诊断放射性同位素的80%。近年来,基于回旋加速器通过核反应^(100)Mo(p,2n)^(99m)Tc直接生产^(99m)Tc已经成为国际上比较认可的方法,具有不需要反应堆、无高浓缩铀、放射性废物少、不存在核扩散风险等优势。本文针对加速器直接生产技术所发展的几种^(99m)Tc化学分离纯化方法进行了详细阐述,包括柱色谱分离、溶剂萃取、化学沉淀以及热色谱法。本工作可为我国开展加速器直接生产^(99m)Tc提供一定的参考。Radioisotope ^(99m)Tc(T_(1/2)=6.01 h)is the decay daughter of ^(99)Mo,which is a widely used radioisotope in nuclear medicine.It accounts for about 80%of all radioactive isotopes used.Recently,the direct production of ^(99m)Tc on cyclotron accelerators via ^(100)Mo(p,2n)^(99m)Tc reaction has been the most promising approach with many advantages,such as nonreactors,no highly enriched uranium,less radioactive waste and no nuclear proliferation.This paper reviews the reported several separation strategies for ^(99m)Tc based on cyclotron production,which includes column chromatography,solvent extraction,chemical precipitation and thermochromatography.This work could provide some theoretical reference for the investigation of direct production of ^(99m)Tc on cyclotron accelerator in China.

关 键 词：医用同位素 ^(99m)Tc 加速器 化学分离纯化 

分 类 号：TL921.1[核科学技术—核燃料循环与材料]