探讨多西环素联合左氧氟沙星治疗女性泌尿生殖道支原体感染的临床疗效  

Explore the clinical efficacy of doxycycline combined with levofloxacin in the treatment of female urogenital mycoplasma infection

作　　者：罗娟[1] 赵漫丽 刘琼花[1] Luo Juan;Zhao Manli;Liu Qionghua(Department of Gynecology, Aoyang Hospital Affiliated to Jiangsu University, Zhangjiagang Jiangsu, 215600, China)

机构地区：[1]江苏大学附属澳洋医院妇科,江苏张家港215600

出　　处：《中外女性健康研究》2021年第21期5-7,共3页Women＇s Health Research

摘　　要：目的分析女性泌尿生殖道支原体感染患者采用多西环素与左氧氟沙星联合治疗方案的临床效果。方法从2018年1月至2019年12月经本院确诊的泌尿生殖道支原体感染女性患者中选取65例,按照随机数字表法分为研究组(例数为33例)和对照组(例数为32例),其中研究组予以多西环素联合左氧氟沙星治疗,对照组仅予以多西环素治疗。于治疗14d结束后评估临床疗效,观察患者临床症状消失时间,统计治疗期间药物不良反应,比较总发生率。结果治疗14d结束后临床总有效率比较,研究组高于对照组(96.97%vs 75.00%),组间差异有统计学意义(P<0.05)。研究组患者外阴瘙痒、阴道分泌物异常以及下腹坠痛症状消失时间明显较对照组短,组间差异有统计学意义(P<0.05)。组间药物不良反应统计结果显示,差异无统计学意义(P>0.05)。结论多西环素联合左氧氟沙星治疗女性泌尿生殖道支原体感染疗效显著,可促进支原体培养转阴,改善症状,且联合用药不会增加药物不良反应发生率。Objective:To analyze the clinical effect of combined treatment with doxycycline and levofloxacin in female patients with mycoplasma infection in the urogenital tract.Methods:From January 2018 to December 2019,65 female patients with mycoplasma infection in the urogenital tract diagnosed in our hospital were selected and divided into study group(33 cases)and control group(32 cases)according to the random number table method,the study group was treated with doxycycline combined with levofloxacin,and the control group was treated with doxycycline only.Evaluate the clinical efficacy after 14 days of treatment;observe the disappearance time of the patient's clinical symptoms;count the adverse drug reactions during the treatment period and compare the total incidence.Results:After 14 days of treatment,the total clinical effective rate was higher in the study group than in the control group(96.97%vs 75.00%),and the difference between the groups was statistically significant(P<0.05).The disappearance of symptoms of genital itching,abnormal vaginal discharge and lower abdominal pain in the study group was significantly shorter than that in the control group,and the difference between the groups was statistically significant(P<0.05).And the statistical results of adverse drug reactions between groups showed that the difference was not statistically significant(P>0.05).Conclusion:The combination of doxycycline and levofloxacin has a significant effect on the treatment of female urogenital mycoplasma infections.It can promote the mycoplasma culture to turn negative,improve symptoms,and the combined drug will not increase the incidence of adverse drug reactions.

关 键 词：女性泌尿生殖道支原体感染 多西环素 左氧氟沙星 转阴率 

分 类 号：R691.3[医药卫生—泌尿科学]