基于“肝肾同源”理论强脊炎方联合针刺治疗早期强直性脊柱炎肝肾不足证疗效观察  

Curative effect of therapy based on theory of"Homogeny of Liver and Kidney"on early ankylosing spondylitis(liver and kidney deficiency)

作　　者：曹志阳 杨利学[1] CAO Zhiyang;YANG Lixue(the First Clinical Medical College of Shaanxi University of Chinese Medicine,Xianyang,Shaanxi 712000;不详)

机构地区：[1]陕西中医药大学第一临床医学院,陕西咸阳712000

出　　处：《河北中医》2021年第9期1435-1439,共5页Hebei Journal of Traditional Chinese Medicine

基　　金：陕西省2018年自然科学基础研究计划项目(编号:2018JM7128);陕西省中医药管理局2017—2018年度中医药科研中标项目(编号:JCPT019);陕西省第二届名中医工作室建设项目。

摘　　要：目的观察基于“肝肾同源”理论强脊炎方联合针刺治疗早期强直性脊柱炎(AS)肝肾不足证的临床疗效。方法将60例早期AS肝肾不足证患者按照随机数字表法分为2组。对照组30例予柳氮磺吡啶肠溶片治疗,治疗组30例在对照组治疗基础上予强脊炎方联合针刺治疗。2组均10 d为1个疗程,共治疗3个疗程。比较2组治疗前后中医证候评分、Bath强直性脊柱炎功能指数(BASFI)评分、红细胞沉降率(ESR)、血清C反应蛋白(CRP)水平及健康调查简表(SF-36)评分,并统计2组疗效。结果治疗组总有效率93.3%(29/30),对照组总有效率73.3%(22/30),治疗组疗效优于对照组(P<0.05)。治疗后2组中医证候各项评分及总分均较本组治疗前降低(P<0.05),且治疗后治疗组均低于对照组(P<0.05)。治疗后2组ESR、CRP水平均较本组治疗前降低(P<0.05),且治疗后治疗组均低于对照组(P<0.05)。治疗后2组BASFI评分均较本组治疗前降低(P<0.05),且治疗后治疗组低于对照组(P<0.05)。治疗后2组SF-36各项评分均较本组治疗前升高(P<0.05),且治疗后治疗组均高于对照组(P<0.05)。结论基于“肝肾同源”理论强脊炎方联合针刺治疗早期AS肝肾不足证疗效显著,患者临床症状明显缓解,躯体功能明显改善,炎症反应明显降低。Objective To observe the clinical efficacy of therapy based on theory of"Homogeny of Liver and Kidney"on early ankylosing spondylitis(AS)with liver and kidney deficiency.Methods Sixty patients with early AS(liver and kidney deficiency)were randomly divided into 2 groups,30 cases in control group were treated with sulfasalazine enteric-coated tablets,and 30 cases in treatment group additionally with Qiangjiyan Formula combined with acupuncture on the basis of control group.The treatment continued for 3 course,1 course for 10 d,the key observation was traditional Chinese medicine(TCM)symptom score,Bath ankylosing spondylitis functional index(BASFI),erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),short form 36 health survey questionnaire(SF-36),as well as curative effects.Results The total effective rates were better in treatment group than in control group[93.3%(29/30)vs 73.3%(22/30),(P<0.05),respectively].After treatment,TCM symptom scores in groups were decreased(P<0.05),which decreased in treatment group when compared with cortrol group(P<0.05);ESR and CRP in groups decreased(P<0.05),improvement of which in treatment group were significantly better(P<0.05);BASFI score in groups was decreased(P<0.05),treatment group was decreased than control group(P<0.05);SF-36 score was increased(P<0.05),treatment group was increased in comparison with control group(P<0.05).Conclusion For early AS(liver and kidney deficiency),the therapy based on theory of"Homogeny of Liver and Kidney"has significant curative effect,can significantly alleviate the clinical symptoms,improve physical function,and reduce inflammatory response.

关 键 词：肝肾同源 脊柱炎 强直性 中药疗法 针刺疗法 

分 类 号：R593.230.531[医药卫生—内科学] R245[医药卫生—临床医学]