健脾化瘀方在原发性肝癌术后的临床应用研究  被引量:4

Clinical Study of JianpiHuayu Recipe on postoperative hepatocellular carcinoma

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作  者:曹学冬[1] 宋鑫 曲岩 陈佳骏[1] 张海阳[1] 罗运权[1] CAO Xuedong;SONG Xin;QU Yan;CHEN Jiajun;ZHANG Haiyang;LUO Yunquan(Department of Hepatobiliary Surgery,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203)

机构地区:[1]上海中医药大学附属曙光医院肝胆外科,上海201203

出  处:《河北中医》2021年第9期1480-1482,1503,共4页Hebei Journal of Traditional Chinese Medicine

摘  要:目的观察健脾化瘀方在原发性肝癌术后临床应用价值。方法将60例原发性肝癌术后患者按照随机数字表法分为2组,对照组30例予术后西医常规治疗,治疗组30例在对照组基础上联合健脾化瘀方治疗。2组均治疗7 d后统计疗效,比较2组术后第1、7天血清丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、白蛋白(Alb)、总胆红素(TBiL)、γ-谷氨酰转移酶(GGT)水平变化情况,比较2组治疗期间术后并发症肺部感染、切口感染、胆瘘、贫血乏力、失眠、胸水的发生情况,比较2组组总住院天数、总住院费用情况。结果与本组术后第1天比较,2组术后第7天血清ALT、AST、TBiL、GGT水平均下降(P<0.05),治疗组Alb水平上升(P<0.05),且治疗组术后第7天血清ALT、AST、Alb、GGT水平改善均优于对照组(P<0.05)。治疗组术后失眠发生率10.0%(3/30),贫血乏力发生率20.0%(6/30),对照组分别为36.7%(11/30)、60.0%(18/30),治疗组术后失眠、贫血乏力的发生率均低于对照组(P<0.05),但2组切口感染、胆瘘、胸水、肺部感染的发生率组间比较差异均无统计学意义(P>0.05)。治疗组总住院天数(10.51±2.35)d,总住院费用(4.65±0.68)万元,对照组分别为(11.23±1.65)d、(4.85±0.87)万元,治疗组虽然均少于对照组,2组组间比较差异无统计学意义(P>0.05)。结论健脾化瘀方应用于原发性肝癌术后疗效确切,可明显改善患者肝功能,减少术后失眠、贫血乏力并发症的发生,对患者疾病的转归和预后均有积极意义。Objective To observe the clinical application value of JianpiHuayu Recipe in Postoperative hepatocellular carcinoma(HCC).MethodsSixty patients with postoperative HCC were randomly divided into a control group(n=30)and an treatment group(n=30).Control group was treated with conventional treatment,treatment group additionally with JianpiHuayu Recipe on the basis of control group.The key observation was the serum alanine aminotransferase(ALT),aspartate aminotransferase(AST),albumin(ALb),total bilirubin(TBiL),andγ-glutamyl transferase(GGT)on day 1 and day 7 postoperation;postoperation complications(pulmonary infection,incision infection,biliary,fistula,anemia,fatigue,insomnia,pleural effusion),as well as total hospitalization days and total hospitalization expenses between groups were compared.ResultsSerum level of ALT,AST,TBiL,and GGT levels on day 7 postoperation were decreased than those on day 1 postoperation(P<0.05),Alb level in treatment group was increased(P<0.05),and serum ALT,AST,Alb,andγ-GT levels improved on day 7 postoperation in treatment group were better than control group(P<0.05).The incidence of postoperative insomnia and anemia,fatigue in treatment group was lower than that in control group[10.0%(3/30)vs 36.7%(11/30),20.0%(6/30)vs 60.0%(18/30),(P<0.05),respectively],no significant difference was found in the incidence of incision infection,and biliary,fistula,pleural effusion,and lung infection between groups(P>0.05).Total hospitalization days and total hospitalization expenses in treatment group were(10.51±2.35)d and(4.65±0.68)ten thousand yuan,which being less than in control group(11.23±1.65)d and(4.85±0.87)ten thousand yuan,respectively;however,the difference between groups was not statistically significant(P>0.05).ConclusionFor postoperative HCC,JianpiHuayu Recipe has definite curative effect,can significantly improve liver function,reduce the incidence of postoperative insomnia,anemia and fatigue,and with positive significance for outcome and prognosis of disease.

关 键 词:肝肿瘤 肿瘤 原发性 中药疗法 

分 类 号:R289.6[医药卫生—方剂学] R735.7[医药卫生—中药学]

 

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