注意缺陷多动障碍合并肥胖患儿肠道菌群特点观察  

Characteristics of intestinal flora in children with ADHD and combined with obesity

作　　者：周国岭[1] 张勋[1] 廖文静 刘艳[1] 俞蓉蓉[2] ZHOU Guo-ling;ZHANG Xun;LIAO Wen-jing;LIU Yan;YU Rong-rong(Department of Child Psychology,Hangzhou Seventh People’s Hospital,Hangzhou,Zhejiang 310000,China;不详)

机构地区：[1]杭州市第七人民医院儿童心理科,浙江杭州310000 [2]浙江工业大学教科学院心理学系,浙江杭州310000

出　　处：《中华全科医学》2021年第12期2061-2064,共4页Chinese Journal of General Practice

基　　金：浙江省医药卫生科技计划项目(2019KY517)。

摘　　要：目的探究注意缺陷多动障碍(ADHD)合并肥胖患儿发病过程中肠道菌群特点。方法选取2018年8月—2019年10月期间杭州市第七人民医院接诊的64例ADHD患儿作为本次研究对象,根据体重指数将其分为正常体重ADHD患儿(对照组,32例)和肥胖伴ADHD患儿(观察组,32例),采用宏基因组测序的方法测定粪便菌群,比较2组儿童之间菌群α多样性、物种分类的相对丰度及菌数量的差异。结果观察组和对照组儿童肠道菌群α多样性差异较小(均P>0.05)。从菌属方面来看,观察组患儿的韦荣球菌属和粪肠杆菌属丰度低于对照组,但气味杆菌属和肠球菌属丰度高于对照组(均P<0.05)。从菌种方面来看,观察组患儿的毛螺科菌、普氏栖粪杆菌、小韦荣球菌以及活泼瘤胃球菌丰度低于对照组,木假单胞菌、粪拟杆菌以及内脏拟杆菌丰度高于对照组(均P<0.05)。对照组患儿的直肠真杆菌菌数明显高于观察组,多形拟杆菌、双歧杆菌属以及乳酸杆菌菌数明显低于观察组(均P<0.05)。结论ADHD合并肥胖患儿肠道菌群发生了改变,或可为ADHD患儿治疗提供参考资料。Objective To discuss and explore the distribution characteristics of intestinal flora in children with attention deficit hyperactivity disorder(ADHD)complicated with obesity.Methods 64 children with attention deficit hyperactivity disorder(ADHD)admitted to Hangzhou Seventh people’s Hospital from August 2018 to October 2019 were divided into 32 children with normal weight ADHD(control group)and 32 obese children with ADHD(experimental observation group).The macrogenomic sequencing method of faecal flora was used to compare theαdiversity of microflora,relative abundance of species classification and differences in the number of bacteria between the two groups of children.Results No significant difference in theαdiversity of intestinal microflora was observed between the experimental group and control group(all P>0.05).With regard to bacteria genus,the abundance of Veillonella and Enterococcus in the experimental observation group was lower than that in the control group,but the abundance of Flavobacteriaceae and Enterococcus in the experimental group was higher than that in the control group(all P<0.05).With regard to bacteria species,the abundance of Lachnospira,Prausnitzii,Veillonella and active rumen cocci in the experimental group was lower than that in the control group,whereas the abundance of Pseudomonas aeruginosa,Bacteroides faecalis and Bacteroides viscera in the experimental group was higher than that in the control group(all P<0.05).The number of rectal true bacteria in the control group was significantly higher than that in the experimental group,whereas the number of Bacteroides polymorpha,Bifidobacterium and Lactobacillus in the control group was significantly lower than that in the experimental group(all P<0.05).Conclusion The changes of intestinal flora in children with ADHD and obesity may provide reference for the treatment of children with ADHD.

关 键 词：注意缺陷多动障碍 肥胖 肠道菌群 儿童 

分 类 号：R729[医药卫生—儿科] R589.2[医药卫生—临床医学]