养血固肾汤治疗绝经后骨质疏松症30例临床观察  

Clinical effect of Yangxue Gushen decoction in treatment of postmenopausal osteoporosis:An analysis of 30 cases

作　　者：陈顺贤[1] 朱春城 王宇胜 CHEN Shunxian;ZHU Chuncheng;WANG Yusheng(Sanshui Hospital,Foshan Hospital of Traditional Chinese Medicine,Foshan 528100,Guangdong,China)

机构地区：[1]佛山市中医院三水医院,广东佛山528100

出　　处：《湖南中医杂志》2021年第11期14-17,共4页Hunan Journal of Traditional Chinese Medicine

基　　金：广东省佛山市医学类科技攻关项目(2018AB000475)。

摘　　要：目的:观察养血固肾汤治疗绝经后骨质疏松症(PMOP)肾虚精亏证的临床疗效。方法:将60例PMOP肾虚精亏证患者随机分成治疗组和对照组,每组各30例。对照组予常规抗骨质疏松药物(阿仑膦酸钠片+碳酸钙D3颗粒)治疗,治疗组在对照组基础上加用养血固肾汤治疗。治疗3个月后比较2组患者的综合疗效、骨密度(BMD)、骨代谢指标[包括血清中骨钙素(BGP)、血清骨碱性磷酸酶(ALP)、β胶原降解产物(β-CTX)]及不良反应发生率。结果:总有效率治疗组为96.67%(29/30),明显高于对照组的80.00%(24/30),差异有统计学意义(P<0.05)。治疗后2组BMD及骨代谢指标(BGP、ALP、β-CTX)均较治疗前明显改善(P<0.05),且治疗组改善程度大于对照组(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:养血固肾汤能改善PMOP肾虚精亏证患者的临床症状,提高BMD,降低骨代谢指标,且临床使用较安全,值得推广应用。Objective:To investigate the clinical effect of Yangxue Gushen decoction in the treatment of postmenopausal osteoporosis(PMOP)with kidney deficiency and essence deficiency.Methods:A total of 60 PMOP patients with kidney deficiency and essence deficiency were randomly divided into treatment group and control group,with 30 patients in each group.The patients in the control group were given conventional anti-osteoporosis drugs(alendronate sodium tablets and calcium carbonate D3 granules),and those in the treatment group were given Yangxue Gushen decoction in addition to the treatment in the control group.After 3 months of treatment,the two groups were compared in terms of overall response,bone mineral density(BMD),bone metabolic markers[serum bone Gla protein(BGP),serum bone alkaline phosphatase(BAP),andβisomer of C-terminal telopeptide of type I collagen(β-CTX)],and incidence rate of adverse events.Results:The treatment group had a significantly higher overall response rate than the control group[96.67%(29/30)vs80.00%(24/30),P<0.05].After treatment,both groups had significant improvements in BMD and the bone metabolic markers BGP,BAP,andβ-CTX(P<0.05),and the treatment group had significantly greater improvements than the control group(P<0.05).There was no significant difference in the incidence rate of adverse events between the two groups(P>0.05).Conclusion:For PMOP patients with kidney deficiency and essence deficiency,Yangxue Gushen decoction can improve their clinical symptoms,increase BMD,and reduce bone metabolic markers and is safe in clinical application.Therefore,it holds promise for clinical application.

关 键 词：绝经后骨质疏松症 养血固肾汤 骨密度 骨代谢指标 

分 类 号：R259.8[医药卫生—中西医结合]