2-(4-羧基苯甲巯基)-5-(4-羟苯基)-1,3,4-噁二唑的合成与表征  

Synthesis and Characterization of 2-(4-Carboxybenzyl Sulfhydryl)-5-(4-Hydroxyphenyl)-1,3,4-Oxadiazole

作　　者：屈树婷 张雪 冷宜泉 石广慧 吴祥雯[1] Qu Shuting;Zhang Xue;Leng Yiquan;Shi Guanghui;Wu Xiangwen(College of Chemistry,Chemical Engineering and Materials Science,Shandong Normal University,Jinan 250014,China)

机构地区：[1]山东师范大学化学化工与材料科学学院,山东济南250014

出　　处：《山东化工》2021年第22期12-13,16,共3页Shandong Chemical Industry

基　　金：山东师范大学大学生创新创业训练计划项目(S202010445131);山东师范大学大型仪器设备开放基金(KFJJ2018011)。

摘　　要：以4-羟基苯甲酸为起始原料经系列反应得中间体4-羟基苯甲酸甲酯、4-羟基苯甲酰肼、2-(4-羟苯基)-5-巯基-1,3,4-噁二唑,最后与制得的对溴甲基苯甲酸经威廉姆森成醚反应得目标产物2-(4-羧基苯甲巯基)-5-(4-羟苯基)-1,3,4-噁二唑,并用核磁共振氢谱和红外光谱对结构予以表征。In this paper,4-hydroxybenzoic acid was used as a starting material to obtain intermediate methyl 4-hydroxybenzoate,4-hydroxybenzohydrazide,2-(4-hydroxyphenyl)-5-sulfhydryl-1,3,4-oxadiazol after a series of reactions.2-(4-hydroxyphenyl)-5-sulfhydryl-1,3,4-oxadiazol was finally reacted with p-bromomethyl benzoic acid to get the target product 2-(4-carboxy benzyl sulfhydryl)-5-(4-hydroxyphenyl)-1,3,4-oxadiazole.The final product was characterized by 1H-NMR and IR spectroscopy.

关 键 词：噁二唑 不对称配体 金属有机化学 

分 类 号：TQ463.53[化学工程—制药化工]