3-吡唑基吲哚的水相合成  

Aqueous Synthesis of 3-Pyrazolyl Indole

作　　者：魏晓毳[1] 苗雪松 Wei Xiaocui;Miao Xuesong(Department of Pharmacy,Baicheng Medical College,Baicheng 137000,China)

机构地区：[1]白城医学高等专科学校药学院,吉林白城137000

出　　处：《山东化工》2021年第22期31-34,共4页Shandong Chemical Industry

基　　金：吉林省教育厅“十三五”科学技术研究规划项目(JJKH20190619KJ)资助。

摘　　要：本文报道了3-吡唑基吲哚的水相合成。研究表明,在100℃回流条件下,水和聚乙二醇400(PEG-400)(体积比为4∶1)混合介质中,β-乙硫基-,β-吲哚基-α,β-不饱和酮与水合肼有效进行环缩合反应,高产率合成3-吡唑基吲哚。反应不仅后处理简单,产物通过过滤就能获得,而且实用性强,能进行产物的克级合成和反应介质回收和循环实用。In the paper,the aqueous synthesis of 3-pyrazolyl indoles was reported.It was found that the cyclocondensation reaction ofβ-ethylthio-β-indoly-α,β-unsaturated ketones and Hydrazine hydrate efficiently occured in 100℃in reaction medium of water and PEG-400(4∶1),to afford 3-pyrazolyl indole in excellent yields.The method is not only simple work-up,in which the product can be obtained by filtration,but also has good practicability,because it can realized gram level synthesis of product and the recyclability and reusability of reaction medium circulation.

关 键 词：水相反应 3-吡唑基吲哚 水合肼 β-乙硫基-β-吲哚基-α β-不饱和酮 

分 类 号：TQ23[化学工程—有机化工] O626[理学—有机化学]