肺爆震伤的分子生物学机制及靶向干预研究进展  

Research progress on the molecular biological mechanisms and the targeted interventions of blast lung injury

作　　者：王俊男 奚望 程彭超 杨潜 王志农 WANG Junnan;XI Wang;CHENG Pengchao;YANG Qian;WANG Zhinong(Department of Cardiothoracic Surgery,Changzheng Hospital,Naval Medical University,Shanghai 200003,China)

机构地区：[1]海军军医大学第二附属医院胸心外科,上海200003

出　　处：《中华灾害救援医学》2021年第12期1417-1421,共5页Chinese Journal of Disaster Medicine

基　　金：军队后勤科研重大项目(AWS15J002);上海市“领军人才”计划(No.2015044);海军军医大学附属长征医院金字塔人才工程优秀青年医师项目。

摘　　要：肺爆震伤(Blast Lung Injury,BLI)由各类爆炸产生的冲击波超压直接作用于肺组织所造成,是爆炸冲击伤最常见的死亡原因之一。冲击波通过散裂力、内爆力和惯性力造成肺泡毛细血管和肺泡壁的广泛损伤,损伤继发氧化应激反应、炎性反应及细胞凋亡反应等,进一步造成急性肺损伤或急性呼吸窘迫综合征。在BLI的细胞与亚细胞水平变化、分子生物学机制和靶向干预等方面,最新研究取得诸多进展,本文从氧化应激反应、炎性反应、细胞凋亡反应及固有免疫应答等方面对相关研究进展进行综述。Being one of the most common causes of explosion related death,Blast Lung Injury(BLI)is caused by the shock wave overpressure on lung tissue from various types of explosions.Shock waves cause extensive damage to alveolar capillaries and alveolar walls through spallation,implosion,and inertia forces,and the injury is secondary to oxidative stress reaction,inflammatory reaction,and apoptotic reaction,which further develops into acute lung injury or acute respiratory distress syndrome.Recent studies on the cellular and subcellular changes,molecular biological mechanisms,and targeted interventions of BLI have achieved much progress.In this paper,the relevant research progress is reviewed from the aspects of oxidative stress reaction,inflammatory reaction,apoptotic reaction,and innate immune response.

关 键 词：肺爆震伤 分子生物学机制 靶向干预 

分 类 号：R655.3[医药卫生—外科学]