腰痹逐瘀止痛汤加刺络放血在腰椎间盘突出症治疗中的作用及对疼痛介质、FIB、Arbc的影响  

Therapeutic Effect of Yaobi Zhuyu Zhitong Decoction(腰痹逐瘀止痛汤)and Blood-Letting Therapy on Lumbar Disc Herniation(Qi Stagnation and Blood Stasis Syndrome)and Its Effects on Pain Mediators,FIB and Arbc

作　　者：徐明兴 张丹红 李颖 XU Mingxing;ZHANG Danhong;LI Ying(The Third Affiliated Hospital of Zunyi Medical University,Zunyi 563000,Guizhou,China)

机构地区：[1]遵义医科大学第三附属医院,贵州遵义563000

出　　处：《中华中医药学刊》2021年第11期59-62,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：国家中医药管理局国家中医临床研究基地业务建设专项(JDZX20186837);贵州省中医药管理局中医药、民族医药科学技术研究专项课题(GZYY-2015-09)。

摘　　要：目的探讨腰痹逐瘀止痛汤加刺络放血在腰椎间盘突出症治疗中的临床效果。方法以随机数字表法,将2017年1月—2019年2月收治的90例腰椎间盘突出症(气滞血瘀证)患者予以分组,对照组45例,接受常规西医治疗,观察组45例,在对照组基础上加腰痹逐瘀止痛汤与刺络放血治疗,观察两组治疗效果,治疗前、治疗4周后疼痛介质、纤维蛋白原(FIB)、红细胞聚集指数(Arbc)、腰椎功能障碍指数(ODI)及日本骨科协会评分(JOA)变化。结果治疗总有效率观察组为95.56%(43/45),与对照组75.56%(34/45)对比,明显较高(P<0.05);治疗前,两组P物质(SP)、多巴胺(DA)、前列腺素E2(PGE2)水平对比,差异无统计学意义(P>0.05),治疗4周后,与同期对照组对比,观察组上述指标水平明显较低(P<0.05);治疗前,两组FIB及Arbc水平对比,差异无统计学意义(P>0.05),治疗4周后,与同期对照组对比,观察组上述指标水平明显较低(P<0.05);治疗前,两组ODI及JOA评分对比,差异无统计学意义(P>0.05),治疗4周后,与同期对照组对比,观察组上述指标情况明显较好(P<0.05)。结论腰痹逐瘀止痛汤加刺络放血在腰椎间盘突出症(气滞血瘀证)治疗中可取得满意疗效,并能降低疼痛介质含量,调节FIB及Arbc水平,改善腰椎功能,值得推广。Objective To explore the clinical effect of Yaobi Zhuyu Zhitong Decoction(腰痹逐瘀止痛汤)and blood-letting therapy in the treatment of lumbar disc herniation.Methods Ninety patients with lumbar disc herniation(Qi stagnation and blood stasis syndrome)treated from Jan 2017 to Feb 2019 were divided into groups by random number table method,45 patients in the control group received conventional western medicine treatment,and 45 patients in the observation group were treated with Yaobi Zhuyu Zhitong Decoction and blood-letting therapy on the basis of the control group.The treatment effects,the changes of pain mediators,fibrinogen(FIB),red blood cell aggregation index(Arbc),oswestry dability index(ODI)and japanese orthopaedic association scores(JOA)before and 4 weeks after treatment of the two groups were observed.Results In the observation group,the total effective rate was 95.56%(43/45)and was significantly higher than that of the the control group(75.56%,34/45)(P<0.05).Before treatment,there was no significant difference in the levels of substance P(SP),dopamine(DA)or prostaglandin E2(PGE2)between the two groups(P>0.05).4 weeks after treatment,compared with those of the control group at the same period,the levels of the above indicators in the observation group were significantly lower(P<0.05).Before treatment,there were no significant difference in the levels of FIB or Arbc between the two groups(P>0.05).4 weeks after treatment,compared with those of the control group at the same period,the levels of the above indicators in the observation group were significantly lower(P<0.05).Before treatment,there were no significant difference in the scores of ODI or JOA between the two groups(P>0.05).4 weeks after treatment,compared with those of the control group at the same period,the above indicators in the observation group were significantly better(P<0.05).Conclusion Yaobi Zhuyu Zhitong Decoction and blood-letting therapy for lumbar disc herniation(Qi stagnation and blood stasis syndrome)can achieve satisfactory re

关 键 词：腰痹逐瘀止痛汤 刺络放血 腰椎间盘突出症 疼痛介质 红细胞聚集指数 纤维蛋白原 

分 类 号：R269.815.3[医药卫生—中西医结合]