头痛Ⅰ号方加减治疗偏头痛的疗效及对自由基紊乱的改善研究  

Study on Curative Effect of Headache No.1 Recipe(头痛Ⅰ号方)in Treatment of Migraine and Improvement of Free Radical Disorder in Patients

作　　者：江飞飞[1] 陈志志 徐晏雯 杨铭[1] JIANG Feifei;CHEN Zhizhi;XU Yanwen;YANG Ming(Quzhou People's Hospital,Quzhou 324000,Zhejiang,China)

机构地区：[1]衢州市人民医院,浙江衢州324000

出　　处：《中华中医药学刊》2021年第11期84-86,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：中华医学会临床医学科研专项(180100735269)。

摘　　要：目的研究头痛Ⅰ号方加减治疗偏头痛的疗效及对患者自由基紊乱的改善情况。方法选取医院2017年5月—2019年5月收治的偏头痛患者120例,采用随机数字法分为两组。对照组给予盐酸氟桂利嗪胶囊治疗,观察组加用头痛Ⅰ号方加减治疗,分析两组患者治疗后的临床效果。结果两组治疗前偏头疼发作情况组间比较,差异不具有统计学意义(P>0.05)。观察组治疗后发作次数(2.68±1.24)次/月、每次发作时间(3.67±1.54)h、疼痛程度分(1.74±0.76)低于对照组(P<0.05)。两组治疗前超氧化物歧化酶(SOD)、丙二醛(MDA)、一氧化氮(NO)水平组间比较,差异不具有统计学意义(P>0.05)。观察组治疗后SOD(107.44±9.10)U/mL水平高于对照组,MDA(4.15±1.41)nmol/L、NO(58.52±8.10)ng/L水平低于对照组(P<0.05)。两组治疗前颅内动脉血流情况组间比较,差异不具有统计学意义(P>0.05)。观察组治疗后颅内动脉血流情况优于对照组(P<0.05)。观察组不良反应发生率(11.67%,7/60)于对照组(8.33%,5/60)比较,差异不具有统计学意义(P>0.05)。结论头痛Ⅰ号方加减治疗偏头痛可改善颅内血流情况,对抗自由基紊乱,且不增加不良反应。Objective To study the effect of Headache No.1 Recipe(头痛Ⅰ号方)in the treatment of migraine and the improvement of free radical disorders.Methods A total of 120 patients with migraine admitted in our hospital from May 2017 to May 2019 were randomly divided into two groups.The control group was treated with Flunarizine Hydrochloric Acid Capsule,and the observation group was treated with Headache No.1 Recipe.The clinical effect of the two groups after treatment was analyzed.Results There was no significant difference in migraine attack between the two groups before treatment(P>0.05).The frequency of attack was(2.68±1.24)times a month,the time of each attack was(3.67±1.54)hours and the score of pain was(1.74±0.76)points,which were lower than those of the control group(P<0.05).There was no significant difference in the levels of malondialdehyde(MDA)or nitric oxide(NO)between the two groups before treatment(P>0.05).There was no significant difference in the levels of MDA or NO between the two groups before treatment(P>0.05).After treatment,the level of SOD[(107.44±9.10)U/mL]and MDA[(4.15±1.41)nmol/L]in the observation group was higher than that in the control group.NO[(58.52±8.10)ng/L]was lower than that in the control group(P<0.05).There was no significant difference in intracranial artery blood flow between the two groups before treatment(P>0.05).After treatment,the observation group's intracranial artery blood flow was better than that of the control group(P<0.05).The incidence of adverse reactions in the observation group(11.67%,7/60)was not significantly different from that in the control group(8.33%,5/60)(P>0.05).Conclusion Headache No.1 Recipe can improve intracranial blood flow,antagonize free radical disorder and do not increase adverse reactions in the treatment of migraine.

关 键 词：头痛Ⅰ号方 偏头痛 自由基 颅内血流 不良反应 

分 类 号：R277.747.2[医药卫生—中医学]