清热降脂颗粒结合生酮饮食对脾虚湿阻型单纯性肥胖疗效及其机制研究  

Effect of Qingre Jiangzhi Granule(清热降脂颗粒)Combined with Ketogenic Diet on Simple Obesity Patients with Spleen Deficiency and Dampness Resistance and Its Mechanism

作　　者：万红[1] 燕树勋[1] 闫诏 张胜威[1] 王娴[1] 赵梦 WAN Hong;YAN Shuxun;YAN Zhao;ZHANG Shengwei;WANG Xian;ZHAO Meng(The First Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450000,Henan,China)

机构地区：[1]河南中医药大学第一附属医院,河南郑州450000

出　　处：《中华中医药学刊》2021年第11期232-235,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：河南省中医药科学研究专项课题(2019JDZX2105,20-21zy3007,2018JDZX018)。

摘　　要：目的探讨清热降脂颗粒结合生酮饮食对脾虚湿阻型单纯性肥胖患者疗效及其相关机制。方法选择2019年6月—2020年6月医院脾虚湿阻型单纯性肥胖患者120例,采用随机数字表法随机分为观察组和对照组各60例。两组患者均进行健康生活方式指导干预。对照组患者给予生酮饮食,观察组在对照组基础上给予清热降脂颗粒治疗。两组治疗疗程3个月。比较两组治疗3个月总有效率;治疗前与治疗3个月体质量指数(BMI)和脂肪百分比,主要证候积分,血脂水平及血清趋化素和网膜素-1水平变化及不良反应。结果观察组治疗3个月总有效率为88.33%(53/60),对照组治疗3个月总有效率为71.67%(43/60)(P<0.05)。两组治疗3个月患者BMI和脂肪百分比低于治疗前(P<0.05);观察组治疗3个月患者BMI和脂肪百分比低于对照组(P<0.05)。两组治疗3个月患者疲乏无力和肢体困重积分低于治疗前(P<0.05);观察组治疗3个月患者疲乏无力和肢体困重积分低于对照组(P<0.05)。两组治疗3个月患者血清LDL-C、TG和TC水平低于治疗前,而HDL-C水平低于治疗前(P<0.05);观察组治疗3个月患者低于血清LDL-C、TG和TC水平低于对照组,而HDL-C水平低于对照组(P<0.05)。两组治疗3个月患者血清趋化素和网膜素-1水平低于治疗前(P<0.05);观察组治疗3个月患者低于血清趋化素和网膜素-1水平低于对照组(P<0.05)。两组均未出现明显不良反应。结论清热降脂颗粒结合生酮饮食对脾虚湿阻型单纯性肥胖患者疗效良好,其机制可能与改善血脂紊乱及降低趋化素和网膜素-1水平有关。Objective To investigate the curative effect of Qingre Jiangzhi Granule(清热降脂颗粒)combined with ketogenic diet on simple obesity patients with spleen deficiency and dampness resistance and its related mechanism.Methods A total of 120 cases of simple obesity with spleen deficiency and dampness resistance in our hospital from June 2019 to June 2020 were randomly divided into observation group(60 cases)and control group(60 cases)by random number table method.Two groups were given healthy lifestyle guidance intervention.The control group was given ketogenic diet,and the observation group was given Qingre Jiangzhi Granule on the basis of the control group.The treatment course of the two groups was 3 months.The total effective rate of the two groups after 3 months of treatment,body mass index(BMI),fat percentage,main symptom score,blood lipid level,serum chemokine and omentin-1 levels before and after 3 months of treatment,and adverse reactions were compared.Results The total effective rate of the observation group was 88.33%(53/60),higher than that of the control group[71.67%(43/60)]after 3 months of treatment(P<0.05).The BMI and fat percentage of the two groups after 3 months of treatment were lower than those before treatment(P<0.05).The BMI and fat percentage of the observation group after 3 months of treatment was lower than that of the control group(P<0.05).After 3 months of treatment,the scores of fatigue and limb weight block in the two groups were lower than those before treatment(P<0.05).The scores of fatigue and limb weight block in the observation group after 3 months of treatment were lower than those of the control group(P<0.05).The levels of serum LDL-C,TG and TC in the two groups after 3 months of treatment were lower than those before treatment,while the levels of HDL-C were lower than those before treatment(P<0.05).The levels of LDL-C,TG and TC in the observation group were lower than those of the control group after 3 months of treatment,while the levels of HDL-C in the observation group wer

关 键 词：清热降脂颗粒 生酮饮食 脾虚湿阻型 单纯性肥胖 疗效 机制 

分 类 号：R259.892[医药卫生—中西医结合]