银杏叶片联合倍他司汀治疗良性阵发性位置性眩晕手法复位后残留症状的疗效观察  

Clinical observation of Yinxingye Tablets combined with betahistine in treatment of residual symptoms of benign paroxysmal positional vertigo after manual reduction

作　　者：葛仪方[1] 谯凤英[1] 刘鼐 王茂林[1] 杨金梁 杨仕蕊[1] 李耀君[1] GE Yi-fang;QIAO Feng-ying;LIU Nai;WANG Mao-lin;YANG Jin-liang;YANG Shi-rui;LI Yao-Jun(First Teaching Hospial of Tianjin University of Traditional Chinese Medicine,National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,Tianjin 300193,China)

机构地区：[1]天津中医药大学第一附属医院国家中医针灸临床医学研究中心,天津300193

出　　处：《现代药物与临床》2021年第11期2370-2374,共5页Drugs & Clinic

摘　　要：目的探讨银杏叶片联合倍他司汀治疗良性阵发性位置性眩晕手法复位后残留症状的临床效果。方法选取2019年1月—2020年8月天津中医药大学第一附属医院收治的120例良性阵发性位置性眩晕患者经成功手法复位后仍有残留症状者,采取随机数字表法将随机分成对照组(n=60)和治疗组(n=60)。对照组口服甲磺酸倍他司汀片,6 mg/次,3次/d。治疗组在对照组基础上口服银杏叶片,1片/次,3次/d。两组均连续治疗7 d。观察两组的临床疗效,比较两组头晕、平衡障碍的缓解时间、前庭症状指数(VSI)、头晕残障问卷(DHI)总分及焦虑自评量表(SAS)、抑郁自评量表(SDS)评分及半年复发率。结果治疗后,治疗组总有效率是96.7%,较对照组的81.7%显著提高(P<0.05)。治疗后,治疗组头晕缓解时间、平衡障碍缓解时间均显著短于对照组(P<0.05)。两组治疗后VSI总分、DHI总分、SAS评分、SDS评分均显著降低(P<0.05);且治疗后,治疗组相关量表评分低于对照组(P<0.05)。随访6个月,治疗组复发率为8.3%,较对照组21.7%显著降低(P<0.05)。结论银杏叶片联合倍他司汀对良性阵发性位置性眩晕经成功手法复位后仍有残余症状患者具有确切的临床疗效,可安全有效且迅速地改善患者残留症状,并对患者焦虑及抑郁症状亦有显著的改善作用,是提高患者生活质量、降低复发风险的良好途径,值得临床推广应用。Objective To investigate the clinical effect of Yinxingye Tablets combined with betahistine in treatment of residual symptoms of benign paroxysmal positional vertigo after manual reduction. Methods A total of 120 patients with benign paroxysmal positional vertigo admitted to First Teaching Hospial of Tianjin University of Traditional Chinese Medicine from January 2019 to August 2020 who still had residual symptoms after successful manual reduction were randomly divided into control group(n=60) and treatment group(n=60) by random number table method. Patients in the control group were po administered with Betahistine Mesilate Tablets, 6 mg/time, three times daily. Patients in the treatment group were po administered with Yinxingye Tablets on the basis of the control group, 1 tablet/time, three times daily. Both groups were treated for 7 d. The clinical efficacy of the two groups were observed,and the remission time of dizziness and balance disorder, vestibular symptom Index(VSI), total score of dizzy disability Questionnaire(DHI), self-rating Anxiety Scale(SAS), self-rating depression Scale(SDS) and half-year recurrence rate of the two groups were compared. Results After treatment, the total effective rate in the treatment group was 96.7%, significantly higher than that in the control group(81.7%)(P < 0.05). After treatment, the relief time of dizziness and balance disorder in treatment group was significantly shorter than that in control group(P < 0.05). VSI total score, DHI total score, SAS score, and SDS score were significantly decreased in 2 groups after treatment(P < 0.05). After treatment, the scores of related scales in the treatment group were lower than those in the control group(P < 0.05). After 6 months of follow-up, the recurrence rate in the treatment group was 8.3%, significantly lower than that in the control group(21.7%)(P < 0.05). Conclusion Yinxingye Tablets combined with betahistine has a definite overall effect in treatment of residual symptoms of benign paroxysmal positional vertigo after man

关 键 词：银杏叶片 甲磺酸倍他司汀片 良性阵发性位置性眩晕 手法复位后残留症状 症状缓解时间 前庭症状指数 头晕残障问卷总分 

分 类 号：R971[医药卫生—药品]