新血宝胶囊联合二维亚铁治疗缺铁性贫血的疗效观察  

Clinical observation of Xinxuebao Capsules combined with two-dimensional ferrous in treatment of iron deficiency anemia

作　　者：刘洁[1] 任建兰[1] 刘文莉[1] 杨琳[1] LIU Jie;REN Jian-lan;LIU Wen-li;YANG Lin(Department of Hematopathology,General Hospital of Tianjin Medical University,Tianjin 300052,China)

机构地区：[1]天津医科大学总医院血液内科,天津300052

出　　处：《现代药物与临床》2021年第11期2381-2385,共5页Drugs & Clinic

摘　　要：目的探讨新血宝胶囊联合二维亚铁颗粒治疗缺铁性贫血的临床疗效。方法选取2019年5月—2021年5月天津医科大学总医院收治的200例缺铁性贫血患者,按照随机数字表法分为对照组和治疗组,每组各100例。对照组口服二维亚铁颗粒,5 g/次,2次/d。治疗组在对照组基础上口服新血宝胶囊,2粒/次,3次/d。所有患者采用上述治疗方案连续治疗4周。观察两组的临床疗效,比较两组临床症状改善时间、血常规指标和铁代谢指标。结果治疗后,治疗组总有效率是98%,显著高于对照组的88%(P<0.05)。治疗过程中,治疗组乏力、头晕、心悸、面色苍白好转时间均显著短于对照组(P<0.05)。治疗后,两组血红蛋白(HGB)、红细胞计数(RBC)、平均红细胞体积(MCV)、网织红细胞计数(RET)水平均较治疗前显著增高(P<0.05),治疗后治疗组血常规指标显著高于对照组(P<0.05)。治疗后,两组血清铁(SI)、血清铁蛋白(SF)水平均较治疗前显著提高,但总铁结合力(TIBC)水平显著降低(P<0.05);治疗后,治疗组患者铁代谢指标改善优于对照组(P<0.05)。治疗后,两组生活满意度评分均显著升高(P<0.05),且治疗后治疗组生活满意度评分高于对照组(P<0.05)。结论新血宝胶囊联合二维亚铁颗粒治疗缺铁性贫血具有较好的临床疗效,可有效改善患者贫血症状,改善血常规指标和铁代谢指标,提高患者生活满意度,值得临床借鉴与推广使用。Objective To investigate the clinical efficacy of Xinxuebao Capsules combined with two-dimensional ferrous in treatment of iron deficiency anemia. Methods A total of 200 patients with iron deficiency anemia admitted to General Hospital of Tianjin Medical University from May 2019 to May 2021 were selected and divided into control group and treatment group according to random number table method, with 100 cases in each group. Patients in the control group were po administered with Compound Ferrous Fumarate and Vitamin B Granules, 5 g/time, twice daily. Patients in the treatment group were po administered with Xinxuebao Capsules on the basis of the control group, 2 grains/times, three times daily. All patients were treated with the above treatment regimen for 4 weeks. The clinical efficacy of the two groups were observed, and the improvement time of clinical symptoms, blood routine indexes and iron metabolism indexes were compared between the two groups. Results After treatment, the total effective rate of the treatment group was 98%, significantly higher than that of the control group(88%)(P < 0.05). During the treatment, the improvement time of fatigue, dizziness, palpitation, and pallor in the treatment group was significantly shorter than that in the control group(P <0.05). After treatment, the levels of hemoglobin(HGB), red blood cell count(RBC), mean red blood cell volume(MCV) and reticulocyte count(RET) in two groups were significantly higher than those before treatment(P < 0.05), and blood routine indexes in treatment group were significantly higher than those in control group(P < 0.05). After treatment, the levels of serum iron(SI) and serum ferritin(SF) in two groups were significantly increased compared with before treatment, but the level of total iron binding ability(TIBC) was significantly decreased(P < 0.05). After treatment, the improvement of iron metabolism index in the treatment group was better than that in the control group(P < 0.05). After treatment, the life satisfaction scores of the two grou

关 键 词：新血宝胶囊 二维亚铁颗粒 缺铁性贫血 血红蛋白 血清铁 血清铁蛋白 总铁结合力 

分 类 号：R973[医药卫生—药品]