微小RNAs调控ABCA1和ABCG1的研究进展  

Research progress on the regulation of ABCA1 and ABCG1 by microRNAs

作　　者：唐小二 唐尚书 唐朝克 TANG Xiaoer;TANG Shangshu;TANG Chaoke(Department of Pathology and Pathophysiology,Basic Medical College,Shaoyang University,Shaoyang 422000,China;Institute of Cardiovascular Disease,Key Laboratory for Arteriosclerology of Hunan Province,Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease,Medical Instrument and Equipment Technology Laboratory of Hengyang Medical College,Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study,Hengyang Medical College,University of South China,Hengyang 421001,China)

机构地区：[1]邵阳学院基础医学院病理与病理生理学教研室,邵阳422000 [2]南华大学衡阳医学院心血管疾病研究所动脉硬化学湖南省重点实验室动脉硬化性疾病湖南省国际科技合作创新基地衡阳医学院仪器设备技术实验室湖南省分子靶标新药研究协同创新中心,衡阳421001

出　　处：《生命的化学》2021年第10期2215-2221,共7页Chemistry of Life

基　　金：湖南省自然科学基金项目(2020JJ4559);国家自然科学基金项目(81770461)。

摘　　要：三磷酸腺苷结合盒转运体A1(ATP binding cassette transporter A1,ABCA1)和三磷酸腺苷结合盒转运体G1(ATP binding cassette transporter G1,ABCG1)促进细胞内胆固醇流出。微小RNAs(microRNAs,miRNAs)包括miR-33、miR-144和miR-758等抑制ABCA1和ABCG1的表达,降低细胞内胆固醇流出,增加细胞内脂质蓄积,促进泡沫细胞的形成和动脉粥样硬化的发生发展。本文主要综述miRNAs对ABCA1和ABCG1表达的调控作用,以及对动脉粥样硬化性心血管疾病发生发展的影响。ATP binding cassette transporter A1(ABCA1)and ATP binding cassette transporter G1(ABCG1)can promote intracellular cholesterol efflux.MicroRNAs(miRNAs)including miR-33,miR-144 and miR-758 inhibit the expression of ABCA1 and ABCG1,reduce intracellular cholesterol efflux and increase intracellular lipid accumulation which promote the formation of foam cells and the occurrence and development of atherosclerosis.This paper mainly reviews the regulation of the expression of ABCA1 and ABCG1 by miRNAs,and its influence on the occurrence and development of atherosclerotic cardiovascular disease.

关 键 词：微小RNAS 三磷酸腺苷结合盒转运体A1 三磷酸腺苷结合盒转运体G1 动脉粥样硬化 

分 类 号：R543.5[医药卫生—心血管疾病]