外泌体在骨质疏松症治疗中的研究进展  

Research progress of exosomes in treatment of osteoporosis

作　　者：段克友 官建中[1,2] DUAN Keyou;GUAN Jianzhong(Department of Orthopaedics,the First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui,233000,P.R.China;Key Laboratory of Anhui Province for Tissue Transplantation,Bengbu Anhui,233000,P.R.China)

机构地区：[1]蚌埠医学院第一附属医院骨科,安徽蚌埠233000 [2]安徽省组织移植重点实验室,安徽蚌埠233000

出　　处：《中国修复重建外科杂志》2021年第12期1642-1649,共8页Chinese Journal of Reparative and Reconstructive Surgery

摘　　要：目的对不同细胞来源外泌体(exosomes,EXOs)在骨质疏松症(osteoporosis,OP)治疗中的研究进展进行综述。方法广泛查阅近年来国内外有关EXOs与OP治疗的文献,归纳分析不同细胞来源EXOs在OP治疗中的相关机制及其临床应用前景。结果BMSCs、成骨细胞、破骨细胞、骨细胞、内皮细胞等多种细胞来源的EXOs参与了骨重建进程中的多个环节,其作用机制涉及骨相关细胞增殖分化的调控、促进血管再生及免疫调节、抑制炎症反应等。EXOs中包含的多种生物活性物质是调控骨重建进程的基础,结合基因工程技术和EXOs载药等手段可进一步提高OP治疗效果。结论动物实验显示多种细胞来源的EXOs对OP具有良好的治疗效果,并具备免疫原性低、稳定性高、靶向能力强、易储存等优点,提示EXOs具有广阔的临床应用前景,有望成为OP治疗的新策略。Objective To review the research progress of exosomes(EXOs)derived from different cells in the treatment of osteoporosis(OP).Methods Recent relevant literature about EXOs for OP therapy was extensively reviewed.And the related mechanism and clinical application prospect of EXOs derived from different cells in OP therapy were summarized and analyzed.Results EXOs derived from various cells,including bone marrow mesenchymal stem cells,osteoblasts,osteoclasts,osteocytes,and endothelial cells,et al,can participate in many links in the process of bone remodeling,and their mechanisms involve the regulation of proliferation and differentiation of bone-related cells,the promotion of vascular regeneration and immune regulation,and the suppression of inflammatory reactions.A variety of bioactive substances contained in EXOs are the basis of regulating the process of bone remodeling,and the combination of genetic engineering technology and EXOs-based drug delivery can further improve the therapeutic effect of OP.Conclusion EXOs derived from different cells have great therapeutic effects on OP,and have the advantages of low immunogenicity,high stability,strong targeting ability,and easy storage.EXOs has broad clinical application prospects and is expected to become a new strategy for OP treatment.

关 键 词：外泌体 骨质疏松症 骨重建 BMSCS 成骨细胞 破骨细胞 骨细胞 内皮细胞 

分 类 号：R580[医药卫生—内分泌]