岩盐气溶胶疗法治疗小儿AR的效果及对IL-10、IL-17的影响  

Effect of Rock Salt Aerosol Therapy on Pediatric AR and Its Effect on IL-10 and IL-17

作　　者：赵丹[1] 卢君[1] 侯旭东[1] ZHAO Dan;LU Jun;HOU Xudong(Jiamusi Maternal and Child Health Hospital,Jiamusi 154002,China;不详)

机构地区：[1]黑龙江省佳木斯市妇幼保健院,黑龙江佳木斯154002

出　　处：《中国医学创新》2021年第32期119-122,共4页Medical Innovation of China

基　　金：黑龙江省卫生健康委科研课题(2019-358)。

摘　　要：目的:探究岩盐气溶胶疗法治疗小儿过敏性鼻炎(allergic rhinitis,AR)的效果及对IL-10、IL-17的影响。方法:选取2018年1-12月于本院治疗的126例AR患儿为本次研究对象,根据AR患儿入院编号先后顺序分为对照组(n=63)与研究组(n=63)。对照组采用口服氯雷他定治疗,研究组在对照组基础上加以岩盐气溶胶疗法治疗。观察并比较两组症状指标评分、T细胞亚群、NK细胞以及白介素-10(IL-10)、白介素-17(IL-17)水平。结果:治疗后,两组流涕、鼻塞、喷嚏、鼻痒评分均低于治疗前,且研究组均低于对照组,差异均有统计学意义(P<0.05)。治疗后,两组CD3^(+)、NK细胞水平较治疗前均升高,且研究组均高于对照组,两组CD4^(+)/CD8^(+)水平较治疗前均降低,且研究组低于对照组,差异均有统计学意义(P<0.05)。治疗后,两组IL-10水平均高于治疗前,IL-17水平均低于治疗前,且研究组均优于对照组,差异均有统计学意义(P<0.05)。结论:岩盐气溶胶疗法能改善AR患儿临床症状,提高免疫水平,抑制机体炎性反应。Objective:To investigate the effect of rock salt aerosol therapy on pediatric allergic rhinitis (AR) and its effects on IL-10 and IL-17.Method:A total of 126 AR children admitted to our hospital from January to December 2018 were selected as the subjects of this study,and they were divided into the control group (n=63) and the study group (n=63) according to the sequence of admission number of AR children.The control group was treated with oral Loratadine,while the study group was treated with rock salt aerosol therapy on the basis of the control group.The changes of symptom index scores,T cell subsets,NK cells and the levels of interleukin-10 (IL-10) and interleukin-17 (IL-17) were observed and compared between two groups.Result:After treatment,the scores of runny nose,stuffy nose,sneezing and nasal itching in two groups were lower than those before treatment,and the study group were lower than those of the control group,the differences were statistically significant (P<0.05).After treatment,the levels of CD3^(+) and NK cells in both groups were higher than those before treatment,and the levels of CD4^(+)/CD8^(+) in both groups were lower than those before treatment,and the level of CD4^(+)/CD8^(+) in study group was lower than that of the control group,the differences were statistically significant (P<0.05).After treatment,the levels of IL-10 in two groups were higher than those before treatment,and the levels of IL-17 in two groups were lower than those before treatment,the study group were better than those of the control group,the differences were statistically significant (P<0.05).Conclusion:Rock salt aerosol therapy can improve the clinical symptoms of AR children,improve the immune level,and inhibit the inflammatory response.

关 键 词：岩盐气溶胶疗法 小儿 变应性鼻炎 白介素-10 白介素-17 T细胞亚群 NK细胞 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]