通过C(sp^(3))-H键活化构建C-P键合成氨基膦酸酯类化合物  

Progress in the Synthesis of Aminophosphonates Compounds by Forming C-P Bonds via C(sp^(3))-H Activation

作　　者：吴江龙 王彦 李典军 杨金会[1] Wu Jianglong;Wang Yan;Li Dianjun;Yang Jinhui(State Key Laboratory of High-effirienry Utilization of Coal and Green Chemical Engineering,College of Chemistry and Chemical Kngineering,Ningxia University,Yinclman,750021)

机构地区：[1]宁夏大学化学化工学院省部共建煤炭高效利用与绿色化工国家重点实验室,银川750021

出　　处：《化学通报》2021年第12期1328-1337,共10页Chemistry

基　　金：宁夏回族自治区重点研发计划项目(2019BDE03002,2021BEG02001,2021BEE03003);国家自然科学基金项目(21861031,21362025);宁夏国家一流学科建设项目(NXYLXK2017A04);宁夏高等学校科学研究项目(NGY2018005)资助。

摘　　要：氨基膦酸酯及其衍生物是一类重要的有机化合物,因其具有抗菌、抗真菌、酶抑制剂和催化抗体活性而广泛应于药物化学和农业化学。通过C(sp^(3))-H键活化构建C-P键是合成氨基膦酸酯衍生物重要方法之一。本文以过渡金属体系和非金属体系进行分类,介绍了近年来通过C(sp^(3))-H键活化方法构建C-P键合成氨基膦酸酯类化合物的研究进展。Amino phosphonates and their corresponding amino phosphonic acids are important organic compounds. Moreover, α-amino phosphonates have broad applications ranging from pharmaceutical chemistry to agricultural chemistry due to their antibacterial, antifungal, enzyme inhibitory, and catalytic antibody activities. It is a primary method for synthesizing functional amino phosphonate compounds using transition metal-catalyzed and metal-free catalyzed by cross-coupling reaction to form C-P bond. It is undeniably attractive to synthesize amino phosphonate compounds by forming C-P bonds via C(sp^(3))-H activation. This paper summarizes the recent advances in synthesizing amino phosphonate compounds by forming C-P bonds via C(sp^(3))-H activation. For a start, the recent advances in synthesis of amino phosphonates by forming C-P bonds via C(sp^(3))-H activation are surveyed based on various transition-metal-catalyzed and metal-free catalyzed types. Taken together, the above results have opened new avenues toward the more mild, efficient and green synthesis of essential amino phosphonate compounds.

关 键 词：过渡金属催化 非金属催化 C(sp^(3))-H键活化 C-P键 氨基膦酸酯药物 

分 类 号：O627.51[理学—有机化学]