山西五台山僧人血尿酸水平测定及相关影响因素分析  

The investigation of the level and influencing factors of serum uric acid among monks and nuns in Wutai Mountain area

作　　者：赵静[1] 张敏[2] 李云[1] 李英妮[1] 郑茜 贾汝琳[1] 张学武[1] 栗占国[1] Zhao Jing;Zhang Min;Li Yun;Li Yingni;Zheng Xi;Jia Rulin;Zhang Xuewu;Li Zhanguo(Department of Rheumatology and Immunology,Peking University People's Hospital&Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis,Beijing 100044,China;Department of Urology,Beijing Chaoyang Hospital,Capital Medical University,Beijing 100020,China)

机构地区：[1]北京大学人民医院风湿免疫科(北京市风湿免疫重点实验室),100044 [2]首都医科大学附属北京朝阳医院泌尿外科,100020

出　　处：《中华风湿病学杂志》2021年第12期800-804,共5页Chinese Journal of Rheumatology

摘　　要：目的了解五台山地区僧人血尿酸水平及其影响因素,探讨血尿酸与血脂、BMI、空腹血糖之间的关系。方法以2016年10月至12月参加体检的五台山僧人为研究对象,其中男性207例,女性261例。体格检查内容包括身高、体质量、血压、血尿酸、血脂、血糖等指标。用尿酸酶法检测血尿酸值,高尿酸血症判断标准为男性>420μmol/L,女性>360μmol/L。应用SPSS 16.0进行统计学分析,组间计量资料比较采用两独立样本t检验,组间计数资料比较采用χ^(2)检验。结果男性僧人的血尿酸平均水平为(372±6)μmol/L,女性僧人为(290±4)μmol/L,男性明显高于女性(t=11.636,P<0.01)。高尿酸血症的总患病率为18.2%(85/468),男性僧人为24.3%(50/207),女性僧人为13.4%(35/261),男性患病率显著高于女性(χ^(2)=8.966,P<0.01)。按不同年龄分层分析,男性高尿酸血症患病率<50岁患病率达到20.3%(42/207),高于≥50岁者的患病率3.9%(8/207)(χ^(2)=26.3,P<0.01);而女性高尿酸血症<50岁患病率为2.7%(7/261),低于≥50岁的患病率10.7%(28/261)(χ^(2)=13.51,P<0.01)。男性和女性的尿酸水平在50~60岁,表现为相反的变化趋势,男性的水平下降,而在女性则上升。高尿酸组的僧人超重和TG异常的检出率显著高于尿酸正常组僧人,分别为71.8%(61/85)与45.2%(173/383)(χ^(2)=19.68,P<0.01)、54.1%(46/85)与19.8%(76/383)(χ^(2)=42.4,P<0.01);而总胆固醇和血糖检出率差异无统计学意义。结论五台山僧人不同年龄、不同性别血尿酸水平差异有统计学意义,男性血尿酸水平明显高于女性,绝经期后女性僧人HUA患病率明显升高。血脂异常、超重等因素与尿酸升高关系密切。Objective To investigate the level and the influencing factors of blood uric acid in monks and nuns in Wutai Mountain area,and to explore the relationship between blood uric acid level and BMI and blood lipids levels.Methods Physical examinations and laboratory tests were performed on monks and nuns in Wutai Mountain area.There were 207 males and 261 females.Physical examination includes height,weight,blood pressure,blood uric acid,blood lipid,blood glucose and other indicators.The blood uric acid level was measured using the uricase method.Chi-square test for trend,and t test were utilized for statistical analysis.Results The average blood uric acid level of the monk and the nun was(372±6)μmol/L and(290±4)μmol/L,respectively.Obviously,the average blood uric acid level of the monk was significantly higher than it in the nun(t=11.636,P<0.01).The total incidence rate of hyperuricemia,which was diagnosed when the blood uric acid level was higher than 420μmol/L in males and the blood uric acid level was higher than 360μmol/L in females.In particular,the incidence rate of hyperuricemia was much higher in the monk(24.3%,50/207)than in the nuns(13.4%,35/261)(χ^(2)=8.966,P<0.01).Analysis by age,the prevalence of hyperuricemia in men was 20.3%(42/207)before the age of 50,which was higher than that after the age of 50(3.9%,8/207)(χ^(2)=26.3,P<0.01);The prevalence of hyperuricemia in women before the age of 50 was 2.7%(7/261),which was lower than that after the age of 50(10.7%,28/261)(χ^(2)=13.51,P<0.01).The uric acid level of men and women between 50-60 years old,showed the opposite trend.The level of uric acid in men decreased and increased in women.In addition,the prevalence of triglyceride abnormalities and overweight was more significantly in monks and nuns with high uric acid than those with the normal uric acid level[71.8%(61/85)vs 45.2%(173/383),χ^(2)=19.68,P<0.01;54.1%(46/85)vs 19.8%(76/383),χ^(2)=42.4,P<0.01];while no significant difference of total cholesterol and blood glucose levels was observed betw

关 键 词：高尿酸血症 代谢疾病 危险因素 

分 类 号：R446.1[医药卫生—诊断学]