工业大麻中大麻二酚的后脱羧协同超临界萃取  

Post-decarboxylation and Supercritical Fluid Extraction of Cannabisdiol From Hemp

作　　者：牟赵杰 贾玉玺 岳旺 李晓玲[2] 倪倍倍[3] MU Zhao-jie;JIA Yu-xi;YUE Wang;LI Xiao-ling;NI Bei-bei(Datong Hemp Biotechnology Research Institute,Qingdao 266500,China;Qingdao Municipal Hospital,Qingdao 266034,China;Department of Pharmacy,the Affiliated Hospital of Qingdao University,Qingdao 266000,China)

机构地区：[1]大通汉麻生物科技研究院,青岛266500 [2]青岛市市立医院,青岛266034 [3]青岛大学附属医院药学部,青岛266000

出　　处：《当代化工》2021年第11期2596-2599,共4页Contemporary Chemical Industry

基　　金：青岛市中医药科研计划(项目编号:2020-zyy054)。

摘　　要：目的:提供一种后脱羧协同超临界萃取制备大麻二酚(CBD)的方法。方法:工业大麻花叶预处理及干燥后进行二氧化碳超临界萃取。萃取温度为20~50℃,压力为10~30MPa,二氧化碳流量为500~900 kg·h^(-1),时间为1~4 h。萃取物经过前处理后进行脱羧。脱羧后的CBD粗油通过分子蒸馏及高效液相色谱纯化,真空浓缩,结晶,制得高纯度CBD晶体。结果:与脱羧前相比,脱羧后CBDA含量明显降低,转化率在75%以上。制得的成品CBD晶体纯度均在99.7%以上,平均质量分数为99.86%。结论:脱羧协同二氧化碳超临界萃取可提高CBD提取效率、降低生产成本,适合工业化大规模生产。Objective:To provide a method for preparing cannabisdiol by post-decarboxylation combined with supercritical fluid extraction.Methods:The industrial hemp leaves were pretreated and dried,and then supercritical fluid extraction was carried on.Extraction temperature was 20~50℃,pressure was 10~30 MPa,carbon dioxide flow rate was 500~900 kg·h^(-1),time was 1~4 h.After pretreatment,the extract was decarboxylated.The decarboxylated CBD crude oil was purified by molecular distillation and high performance liquid chromatography,concentrated in vacuum and crystallized.At last,high-purity CBD crystals could be obtained.Results:The content of CBDA was markedly decreased after decarboxylation.The conversion rate was above 75%.The purity of CBD crystals was above 99.7%,and the average mass fraction was 99.86%.Conclusion:Decarboxylation combined with supercritical carbon dioxide extraction can improve CBD extraction efficiency and reduce production costs,which is suitable for large-scale industrial production.

关 键 词：大麻叶提取物 大麻二酚 脱羧 

分 类 号：TQ461[化学工程—制药化工]