超声刺激下水凝胶疏水药物释放行为研究  

The Researh of Hydrogel Controllably Release Hydrophobic Drugs under Ultrasound

作　　者：王有朋[1] 李薇[1] 石星丽[1] 吕维华[1] 张歆婕 WANG You-peng;LI Wei;SHI Xing-li;LV Wei-hua;ZHANG Xin-jie(School of Petrochemical Engineering Lanzhou Petrochemical College of Vocational Technology,Lanzhou 730060,China)

机构地区：[1]兰州石化职业技术学院石油化学工程学院,兰州730060

出　　处：《高分子通报》2021年第11期64-70,共7页Polymer Bulletin

基　　金：甘肃省高等学校科研项目(2020A-194);兰州石化职业技术学院科研项目(KJ2019-02);甘肃省科技重点研发计划项目(19YF3GA002);甘肃省高等学校产业支撑计划项目(2020C-33)。

摘　　要：PVA水溶液与溶解疏水药物的硅油混合后经冷冻解冻处理可制得一种高韧性物理水凝胶。荧光显微镜发现这种水凝胶具有良好的结构稳定性,硅油在水凝胶中以小液滴形式分散,五周以后观察不到液滴聚集或明显的相分离。水凝胶的机械性能随着硅油含量增加而增大,表明硅油不仅作为药物储存器来封装疏水性药物,还与PVA链疏水界面产生强吸附性能。本研究系统考察了复合水凝胶超声控制下的疏水药物的释放行为,超声刺激能明显加快水凝胶的药物释放速率。超声引发药物释放机理表明,超声机械效应是诱导疏水药物释放的主要原因。Use freezing/thawing treatment prepared a high toughness composite hydrogel from hydrophobic drug-loaded silicone oil dispersed in poly(vinyl alcohol)solution.The hydrogel owned a relatively stable structure through fluorescent microscopy,silicone oil was dispersed and permeated in the hydrogel matrix as microdroplets,no aggregation or migration were observed when the hydrogel sample was placed stationary after 5 weeks.The mechanical properties of hydrogel enhanced proportionally with increasing the silicone oil content,indicating silicone oil not only act as drug reservoirs dispersed within the hydrogel matrix,but also improved the mechanical properties for strong adsorption effect of PVA chains on hydrophobic surfaces.Ultrasound is used to control trigger the hydrophobic drug release from the hydrogel,the result showed the drug were instantly and rapidly released under ultrasound exposure.Mechanism of ultrasound controlled drug release is studied in this paper,and the results indicate the mechanical effect is the main reason.

关 键 词：超声 水凝胶 控制释放 疏水药物 聚乙烯醇 

分 类 号：TQ427.26[化学工程] TQ460.4