疏肝理气祛斑汤联合超声波导入左旋维生素C治疗气滞血瘀型黄褐斑临床研究  

Clinical Study on the Treatment of Qi-stagnation and Blood-stasis Chloasma with Shugan Liqi Quban Decoction Combined withIntroduction of L-Vitamin C by Ultrasonic Wave

作　　者：王希 王万春[2] 陈琦[1] 刘良[1] 吴斐 孙波 江鑫 WANG Xi;WANG Wan-chun;CHEN Qi;LIU Liang;WU Fei;SUN Bo;JIANG Xin(Jiangxi University of Chinese Medicine,Nanchang 330004,China;The Affiliated Hospital of Jiangxi University of Chinese Medicine,Nanchang 330006,China)

机构地区：[1]江西中医药大学,南昌330004 [2]江西中医药大学附属医院,南昌330006

出　　处：《江西中医药大学学报》2021年第6期33-36,共4页Journal of Jiangxi University of Chinese Medicine

基　　金：江西省研究生创新专项资金项目(YC2018—S272)。

摘　　要：目的:探讨疏肝理气祛斑汤联合超声波导入左旋维生素C治疗气滞血瘀型黄褐斑的临床疗效及作用机制,并评价该治疗方法的安全性及复发率。方法:选取符合诊断标准的黄褐斑患者60例,随机分为观察组、对照组A、对照组B,每组各20例。观察组给予疏肝理气祛斑汤+超声波导入左旋维生素C,对照A组给予疏肝理气祛斑汤,对照B组给予超声波导入左旋维生素C,三组患者均以1个月为1个疗程。3个疗程后,记录治疗前后患者的皮损颜色、面积积分以及中医证候积分,检测患者血清SOD、MDA、E_(2)水平。疗程结束后,比较三组患者的临床疗效。结果:治疗结束后,观察组有效率90.0%,对照A组有效率为57.9%,对照B组有效率为63.2%,三组之间比较有差异性(P<0.05);三组患者的皮损颜色、面积积分及中医证候积分均较治疗前降低(P<0.05),且观察组的疗效明显优于其余两组(P<0.05);三组患者的SOD、MDA水平亦较治疗前均有改善(P<0.05),且观察组疗效更佳(P<0.05);对于E_(2)水平,通过比较显示,观察组与对照A组的疗效较治疗前有所改善(P<0.05),但两组之间的比较不具有差异性(P>0.05),对照B组对于改善E_(2)水平无明显疗效。结论:疏肝理气祛斑汤联合超声波导入左旋维生素C治疗气滞血瘀型黄褐斑可有效改善患者的皮损积分及中医证候积分,并可能通过提高SOD水平,降低MDA水平,以及调节E_(2)水平起作用,临床治疗有效且安全,值得进一步研究。Objective:To investigate the clinical efficacy and mechanism of Shugan Liqi Quba Decoction combined with Introduction of L-Vitamin C by Ultrasonic Wave in the treatment of Chloasma with qi-stagnation and blood-stasis,and to evaluate the safety and recurrence rate of this treatment.Methods:Sixty patients with chloasma with the diagnostic criteria were randomly divided into observation,control A group and control B group with 20 cases in each group.The observation groupwas treated with Shugan Liqi Quban decoction combined withIntroduction of L-Vitamin C by Ultrasonic Wave,the control group A was given Shugan Liqi Quban Decoction,and the control group B was given Introduction of L-Vitamin C by Ultrasonic Wave.Three groups of patients were treatment with a month for a course After three courses of treatment,to record the skin color,area and TCM syndrome integralof the three groups and to detect the serum SOD,MDA,E_(2) level,and to compare the clinical curative effect after 3 course of treatment.Results:After treatment,the effective rate was 90.0%in the observation group,57.9%in the control group A and 63.2%in the control group B.The skin lesion color,area score and TCM syndrome score of the three groups were all lower than those before treatment(P<0.05),and the curative effect of the observation group was significantly better than that of the other two groups(P<0.05).SOD,MDA level of three groups of patients before treatment were also improved(P<0.05),better curative effect and observation group(P<0.05),for E_(2) level,through the comparison showed that the curative effect of observation group and control group A improved than before treatment(P<0.05),but the comparison between the two groups have no difference(P>0.05),control group B to improve E_(2) level no obvious curative effect.Conclusion:The treatment of qi-stasis chloasma with Shugan Liqi Quban decoction combined with Introduction of L-Vitamin C by Ultrasonic Wave can effectively improve the skin damage score and TCM syndrome score of patients,and may play a

关 键 词：疏肝理气祛斑汤 超声波导入左旋维生素C 气滞血瘀型 黄褐斑 

分 类 号：R758.42[医药卫生—皮肤病学与性病学]