Cu/Picolinamides-Catalyzed Coupling of (Hetero) aryl Halides with Secondary Phosphine Oxides and Phosphite  

作　　者：Chao Fang Bangguo Wei Dawei Ma 

机构地区：[1]Department of Natural Medicine,School of Pharmacy,Fudan University,826 Zhangheng Road,Shanghai,201203 China [2]State Key Laboratory of Bioorganic&Natural Products Chemistry,Center for Excellence in Molecular Synthesis,Shanghai Institute of Organic Chemistry,University of Chinese Academy of Sciences,Chinese Academy of Sciences,345 Lingling Lu,Shanghai,200032 China

出　　处：《Chinese Journal of Chemistry》2021年第11期2957-2961,共5页中国化学（英文版）

基　　金：The authors are grateful to Chinese Academy of Sciences(supported by the Strategic Priority Research Program,grant XDB20020200&QYZDJ-SSW-SLH029);the National Natural Science Foundation of China(grant 21621002,21831009 and 21991110)for their financial support.

摘　　要：Some 4-hydroxy-picolinic acid derived amides were revealed as more efficient ligands for Cu-catalyzed coupling of(hetero)aryl halides with secondary phosphine oxides and phosphites.Only 3—5 mol%CuI and ligands were required to ensure coupling with a number of(hetero)aryl bromides and iodides to complete at 120 ℃ in 10—20 h.

关 键 词：Synthetic methods CROSS-COUPLING Aryl halides Copper Aryl phosphine oxides 

分 类 号：O62[理学—有机化学]