Regio-and Stereoselective Synthesis of(Z)-3-Ylidenephthalides via H_(3)PMo1_(2)O_(40)-Catalyzed Cyclization of 2-Acylbenzoic Acids with Benzylic Alcohols  

作　　者：Guoping Yang Ke Li Xiaoling Lin Yijin Li Chengxing Cui Shixiong Li Yuanyuan Cheng Yufeng Liu 

机构地区：[1]Jiangxi Key Laboratory for Mass Spectrometry and Instrumentation,Jiangxi Province Key Laboratory of Synthetic Chemistry,East China University of Technology,Nanchang,Jiangxi,330013 China [2]School of Chemical Engineering and Resource Recycling,Wuzhou University,Wuzhou,Guangxi 543002,Chino [3]School of Chemical and Chemical Engineering,Henon Institute of Science and Technology,Xinxiang,Henon 453003,China

出　　处：《Chinese Journal of Chemistry》2021年第11期3017-3022,共6页中国化学（英文版）

基　　金：the National Natural Science Foundation of China(Nos.22001034 and 21804019);the Open Fund of the Jiangxi Province Key Laboratory of Synthetic Chemistry(No.JXSC202008);the Research Found of East China University of Technology(Nos.DHBK2019265,DHBK2019267,DHBK2019264)for financial support.

摘　　要：We report an exclusively tandem C—O and C—C bond forming beyond the esterification and cyclization reaction of 2-acylbenzoic acids with alcohols to regio-and stereoselective synthesis of the(Z)-3-ylidenephthalides.The reaction uses the nontoxic,inexpensive H_(3)PMo1_(2)O_(40) as catalyst and produces water as the sole by-product,making the reaction environmentally benign and sustainable.Moreover,this reaction features an eco-friendly reaction condition,facile scalability,and easy derivatization of the products to drugs and bioactive compounds.The mechanism studies and density functional theory calculations reveal that the appropriate acid catalyst is the key to the selectivity of this transformation.

关 键 词：POLYOXOMETALATES CHEMOSELECTIVITY CYCLIZATION (Z)-3-Ylidenephthalides Benzylic alcohols 

分 类 号：O626[理学—有机化学]