2,6-二氯-3-三氟甲基吡啶选择性加氢制备2-氯-3-三氟甲基吡啶  

Preparation of 2-chloro-3-trifluoromethylpyridine by Selevtive Hydrogenation of 2,6-Dichloro-3-trifluoromethylpyridine

作　　者：陈洪龙 岳瑞宽 王文魁 罗超然 丁永山 CHEN Honglong;XUE Ruikuan;WANG Wenkui;LUO Chaoran;DING Yongshan(Nanjing Red Sun Biochemical Co.,Ltd.,Nanjing 210047,China)

机构地区：[1]南京红太阳生物化学有限责任公司,江苏南京210047

出　　处：《化工技术与开发》2021年第12期20-21,25,共3页Technology & Development of Chemical Industry

摘　　要：以自制的钯碳为催化剂,2,6-二氯-3-三氟甲基吡啶为原料,经选择性加氢反应,制备得到2-氯-3-三氟甲基吡啶。考察了载体类型、Pd负载量、反应温度、缚酸剂对反应的影响。在最佳的反应条件下,2,6-二氯-3-三氟甲基吡啶的转化率可达94.8%,2-氯-3-三氟甲基吡啶的选择性可达96.5%。Applied self-prepared Pd/C as catalyst,2-chloro-3-trifluoromethylpyridine was prepared by selective hydrogenation of 2,6-dichloro-3-trifluoromethylpyridine.The effects of the character of support,the amount of palladium,the temperature and acid-binding agent on the reaction were investigated.The conversion of 2,6-dichloro-3-trifluoromethylpyridine was 94.8%and the selectivity of 2-chloro-3-trifluoromethylpyridine was 96.5%under the optimum reaction conditions.

关 键 词：2 6-二氯-3-三氟甲基吡啶 加氢 钯碳 2-氯-3-三氟甲基吡啶 

分 类 号：TQ253.2[化学工程—有机化工]