口服普萘洛尔治疗婴幼儿血管瘤的效果观察  

Clinical observation of oral propranolol in the treatment of infantile hemangioma

作　　者：高妹花[1] 刘学英[1] 高阳[1] 李攀[1] 王会肖[1] GAO Mei-hua;LIU Xue-ying;GAO Yang;LI Pan;WANG Hui-xiao(Department of Hemangioma, Hebei Children′s Hospital, Shijiazhuang 050031, China)

机构地区：[1]河北省儿童医院血管瘤科,河北石家庄050031

出　　处：《河北医科大学学报》2021年第12期1432-1436,共5页Journal of Hebei Medical University

摘　　要：目的观察普萘洛尔治疗婴幼儿血管瘤的临床疗效。方法回顾性分析在我院门诊收治的血管瘤婴儿300例,其中观察组150例口服普萘洛尔治疗,对照组150例口服泼尼松治疗。2组患儿定期门诊复诊,采用直观、手工测量、彩色多普勒超声或MRI等方法动态观察患者血管瘤范围、颜色变化、质地及不良反应。结果观察组与对照组相比,瘤体明显缩小,瘤体缩短消退时间明显缩短,差异有统计学意义(P<0.001)。此外,观察组的治疗有效率(94.00%)显著高于对照组(82.67%),且观察组服用普萘洛尔后发生的不良反应明显低于对照组(P<0.01)。结论口服普萘洛尔治疗婴儿血管瘤疗效显著,且无明显不良反应。Objective To observe the clinical efficacy of oral propranolol in the treatment of infantile hemangioma.Methods Retrospective analysis was performed on 300 infants with hemangioma diagnosed in the Outpatient Department of our hospital.Among them,150 in the observation group were treated with propranolol,and 150 patientsin the control group were treated with prednisolone therapy.Two groups of children had regular outpatient follow-up visit,and direct observation,manual measurement,color Doppler ultrasound or MRI and other methods were performed to observe the hemangioma area,color change,texture and adverse reactions.Results The tumor size of observation group was significantly smaller than that of the control group,and the time of spontaneous regression was shortened,suggesting significant difference(P<0.001).Furthermore,the effective rate of the observation group(94.00%)was significantly higher than that of the control group(82.67%),and the adverse reactions of the observation group were significantly lower than those of the control group(P<0.01).Conclusion Oral propranolol is effective in the treatment of infantile hemangioma without obvious adverse reactions.

关 键 词：血管瘤 普萘洛尔 治疗结果 

分 类 号：R732.2[医药卫生—肿瘤]