Akkermansia muciniphila的培养方法及其在疾病治疗中应用的研究进展  

Research progress on the culture methods of Akkermansia muciniphila and its application in the treatment of diseases

作　　者：楚福英 李元敬 王雨亭 施树良[4] 张彦龙[1,2] 雷虹 李文辉[1,2] CHU Fu-Ying;LI Yuan-Jing;WANG Yu-Ting;SHI Shu-Liang;ZHANG Yan-Long;LEI Hong;LI Wen-Hui(Key Laboratory of Molecular Biology, College of Life Sciences, Heilongjiang University, Harbin 150080, China;Engineering Research Center of Ministry of Education, Heilongjiang University, Harbin 150500, China;School of Marine and Environmental Engineering, Shanwei Campus, South China normal University, Shanwei 516600, Guangdong,China;School of Life Science and Technology, Harbin Institute of Technology, Harbin 150001, China)

机构地区：[1]黑龙江大学生命科学学院黑龙江省普通高校分子生物学重点实验室,哈尔滨150080 [2]黑龙江大学农业微生物技术教育部工程研究中心,哈尔滨150500 [3]华南师范大学汕尾校区海洋与环境工程学院,广东汕尾516600 [4]哈尔滨工业大学生命科学与技术学院,哈尔滨150001

出　　处：《黑龙江大学工程学报》2021年第4期84-90,共7页Journal of Engineering of Heilongjiang University

基　　金：黑龙江省自然科学基金项目(c2015023);黑龙江省森林工业总局科技计划项目(sgzjY2015016)。

摘　　要：嗜黏蛋白阿克曼菌是定殖在胃肠道黏液层中的可以特异性的降解黏蛋白的严格厌氧的革兰氏阴性菌,最初是从人体粪便中分离出来的,在各种疾病的治疗过程中发挥着重要作用,有望成为下一代益生菌。综述了现有的嗜黏蛋白阿克曼菌的培养方法,准确地认识嗜黏蛋白阿克曼菌与肥胖、早衰和阿尔兹海默症之间的关系,有利于为这些疾病的治疗提供新的治疗思路和理论依据。Akkermansia muciniphila is a strictly anaerobic gram-negative bacterium that colonized the mucus layer of the gastrointestinal tract and can degrade mucin specifically.Akkermansia muciniphila,which was originally isolated from human feces,plays an important role in the treatment of various diseases and is expected to become the next generation of probiotics.The existing culture methods of Akkermansia muciniphila was reviewed,and had an accurate understanding of the relationship between Akkermansia muciniphila and obesity,premature aging and Alzheimer's disease,which is conducive to providing new treatment ideas and theoretical basis for the treatment of these diseases.

关 键 词：嗜黏蛋白阿克曼菌 培养方法 肥胖 早衰 阿尔兹海默症 

分 类 号：R392.12[医药卫生—免疫学]