维生素D及其类似物对肾脏病患儿的保护作用  

Protection effects of vitamin D and its analogues on children with pediatric kidney diseases

作　　者：尚慧 陶于洪[1] Shang Hui;Tao Yuhong(Department of Pediatrics Nephrology,Key Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University),Ministry of Education,West China Second University Hospital,Sichuan University,Chengdu 610041,Sichuan Province,China)

机构地区：[1]四川大学华西第二医院小儿肾脏科、出生缺陷与相关妇儿疾病教育部重点实验室,成都610041

出　　处：《中华妇幼临床医学杂志（电子版）》2021年第5期497-502,共6页Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)

基　　金：四川省科技厅应用基础研究项目(2017JY0076)。

摘　　要：维生素D是脂溶性维生素,通过其活性形式作用于维生素D受体(VDR)发挥作用。除了调节钙、磷代谢外,维生素D还具有免疫调节、抑制炎症、调节细胞生长分化、促进骨骼生长、抑制肿瘤细胞增殖等多种作用。肾脏病患儿普遍存在维生素D不足。笔者拟就维生素D及其类似物的分类,对肾脏病患儿的肾脏保护作用机制,如合理补充维生素D及其类似物可以通过抑制肾素-血管紧张素-醛固酮系统(RAAS)活性、保护足细胞、降低蛋白尿水平、缓解肾脏炎症、延缓肾脏纤维化和预防心血管疾病等多种机制,对肾脏病患儿肾脏发挥保护作用等进行阐述。Vitamin D is a fat-soluble vitamin,which plays a role through its active forms acting on vitamin D receptor(VDR).In addition to the role of regulating calcium and phosphorus metabolism,vitamin D also has various nonclassical effects,such as immunoregulation,inhibiting inflammation,regulating cell growth and differentiation,promoting bone growth,anti-tumor cell proliferation and so on.Vitamin D deficiency is common in children with kidney disease.This paper intends to focus on the classification of vitamin D and its analogues,and their mechanisms of protecting pediatric kidney diseases,including inhibiting activity of renin-angiotensin-aldosterone system(RAAS),protecting podocytes,reducing proteinuria,relieving renal inflammation,delaying renal fibrosis,preventing cardiovascular diseases,and so on.

关 键 词：维生素D 维生素D类似物 肾疾病 肾小球肾炎 肾病综合征 狼疮肾炎 慢性肾脏病 肾脏保护 儿童 

分 类 号：R69[医药卫生—泌尿科学]