口腔菌群与儿童常见非口腔性疾病的关系  

Current research status between oral microbiome and common non-oral diseases in children

作　　者：杨蕾 肖东琼[2] 钟亦思[3] Yang Lei;Xiao Dongqiong;Zhong Yisi(Department of Pediatrics,Key Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University),Ministry of Education,West China Second University Hospital,Sichuan University,Chengdu 610041,Sichuan Province,China;Department of Emergency,West China Second University Hospital,Sichuan University,Chengdu 610041,Sichuan Province,China;West China School/Hospital of Stomatology,Sichuan University,Chengdu 610041,Sichuan Province,China)

机构地区：[1]四川大学华西第二医院儿科、出生缺陷与相关妇儿疾病教育部重点实验室,成都610041 [2]四川大学华西第二医院急诊科,成都610041 [3]四川大学华西口腔医院,成都610041

出　　处：《中华妇幼临床医学杂志（电子版）》2021年第5期510-515,共6页Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)

基　　金：四川省科技厅应用基础研究项目(2021YJ0229)。

摘　　要：口腔处于人体消化道的最上游,有许多截然不同的微环境,亦是病原体进入人体的主要途径之一。与成年人相比,儿童口腔正常菌群随着生长发育而处于动态变化中,对外界刺激也更为敏感。儿童口腔菌群异常变化,与多种疾病的发生、发展密切相关。因此,通过口腔对儿童进行非侵入性生物样品采集,对某些疾病的快速辅助诊断具有重要意义。笔者拟就儿童口腔菌群的建立及其特点,以及近年对口腔菌群异常变化在儿童哮喘、过敏性紫癜(HSP)、肥胖、阑尾炎和炎症性肠病(IBD)等常见疾病中作用的最新研究进展进行阐述,旨在为儿童非口腔性疾病的辅助诊断提供参考。Oral cavity is at the uppermost part of human digestive tract.There are many distinct microenvironments in oral cavity,and oral cavity is the main way for pathogens to enter human body.Compared with adults,the oral microbiome in children changes dynamically with body′s growth,and it is more sensitive to external stimulation.The abnormal changes of oral microbiome in children are closely related to occurrence and development of a variety of diseases.Therefore,non-invasive biological samples can be collected through oral cavity to assist in immediate detection and rapid diagnosis of some diseases for children,and it is of great significance.This article summarizes establishment and characteristics of children′s oral microbiome,focuses on research advances in relationship between oral microbiome and children′s some non-oral diseases in recent years,including asthma,Henoch-Schonlein purpura(HSP),obesity,appendicitis and inflammatory bowel disease(IBD),in order to provide evidences for auxiliary diagnosis of children′s some non-oral diseases.

关 键 词：病理学 口腔 感染控制 口腔 慢性病患者口腔医疗 消化系统和口腔生理学现象 口腔菌群 生物学标记 儿童 

分 类 号：R72[医药卫生—儿科]