ACTH、Cor及PAI-1在创伤性骨折中的表达及临床意义  

Expressions and Clinical Significances of ACTH,Cor and PAI-1 in Traumatic Fractures

作　　者：李亮 周思私 袁发 冯志尉 LI Liang;ZHOU Si-si;YUAN Fa;FENG Zhi-wei(Department of Orthopedics,Central Hospital of Nanchong City,Nanchong,Sichuan 637000,China)

机构地区：[1]南充市中心医院骨科,四川南充637000

出　　处：《解放军医药杂志》2021年第12期43-46,共4页Medical & Pharmaceutical Journal of Chinese People’s Liberation Army

基　　金：四川省卫计委科研项目(19PJ232)。

摘　　要：目的分析促肾上腺皮质激素(ACTH)、皮质醇(Cor)及纤溶酶原激活物抑制剂-1(PAI-1)在创伤性骨折中的表达及临床意义。方法将2019年8月—2020年12月就诊的创伤性骨折116例作为研究组,根据英国国家早期预警评分(NEWS)分为低危组66例、中危组39例、高危组11例。选择同期体检的健康志愿者124例为对照组。比较研究组与对照组血清ACTH、Cor及PAI-1水平,不同严重程度患者血清ACTH、Cor及PAI-1水平;分析创伤性骨折患者血清ACTH、Cor及PAI-1水平与NEWS的相关性。结果研究组血清ACTH、Cor及PAI-1水平高于对照组(P<0.01)。中危组和高危组血清ACTH、Cor及PAI-1水平均高于低危组,且高危组高于中危组(P<0.05)。创伤性骨折患者血清ACTH、Cor及PAI-1水平与NEWS呈正相关关系(r=0.843、0.694、0.725,P<0.05)。结论血清ACTH、Cor及PAI-1在创伤性骨折患者中表达水平异常升高,三者与患者病情严重程度呈显著相关性,可作为评估病情严重程度的有效依据。Objective To analyze expressions and clinical significances of adrenocorticotropic hormone(ACTH),cortisol(Cor)and plasminogen activator inhibitor type-1(PAI-1)in patients with traumatic fractures.Methods A total of 116 patients with traumatic fractures admitted between August 2019 and December 2020 were selected as research group,and the patients were divided into low-risk subgroup(n=66),intermediate-risk subgroup(n=39)and high-risk subgroup(n=11)according to the British national early warning score(NEWS).In the meantime,124 healthy volunteers who had undergone physical examinations at the same period were selected as control group.ACTH,Cor and PAI-1 levels were compared between research and control groups.Levels of ACTH,Cor and PAI-1 in patients with different severity degrees were compared,and correlations between levels of ACTH,Cor and PAI-1 in patients with traumatic fractures with NEWS were analyzed.Results Serum levels of ACTH,Cor and PAI-1 in research group were significantly higher than those in control group(P<0.01).Serum levels ACTH,Cor and PAI-1 in intermediate-risk subgroup and high-risk subgroup were significantly higher than those in low-risk subgroup,and the levels in high-risk subgroup were significantly higher than those in intermediate-risk subgroup(P<0.05).Serum levels of ACTH,Cor and PAI-1 were positively correlated with NEWS in patients with traumatic fractures(r=0.843,0.694,0.725,P<0.05).Conclusion Serum levels of ACTH,Cor and PAI-1 are abnormal increased in patients with traumatic fractures,which are significantly correlated with the severity of the patients'conditions,and their expressions may be used as effective basis for evaluating the severity of the conditions.

关 键 词：创伤和损伤 骨折 促肾上腺皮质激素 皮质醇 纤溶酶原激活物抑制物1 英国国家早期预警评分 

分 类 号：R683[医药卫生—骨科学]