Ⅲ型干扰素在抗人类免疫缺陷病毒感染中的作用  

Effect of type Ⅲ interferon on anti-HIV infection

作　　者：丁亚 姚静 彭小青 梁辉勇 苏齐鉴[1,3] DING Ya;YAO Jing;PENG Xiaoqing;LIANG Huiyong;SU Qijian(Guangxi University of Chinese Medicine,Nanning 530200,China;不详)

机构地区：[1]广西中医药大学,南宁530200 [2]广西中医药大学附属瑞康医院,南宁530011 [3]钦州市第一人民医院,广西钦州535000

出　　处：《实用医学杂志》2021年第23期2963-2966,共4页The Journal of Practical Medicine

基　　金：国家自然科学基金项目(编号:81360258);广西中医药大学广西一流学科建设开放课题(编号:2019XK158)。

摘　　要：Ⅲ型干扰素由IFN-λ1、IFN-λ2、IFN-λ3和新发现的IFN-λ4组成,与Ⅰ型干扰素激活共同信号通路,生物活性相似,具有抗病毒、抗肿瘤、抗细胞增殖和免疫调节等作用,在抗HIV感染中起重要作用。最初研究发现白细胞白介素28B的基因多态性与丙型肝炎病毒感染者治疗应答及自发清除相关,IL-28基因多态性可用来预测HCV感染的干扰素治疗效果和临床指导用药,使得该位点成为研究热点。而干扰素的抗病毒共性也引起了学者关于IL-28基因多态性与HIV感染相关性的关注,近来不少研究发现IFNL3/4基因座的遗传变异与艾滋病疾病易感性、抗病毒免疫应答和疾病进程存在相关性,而IFNL基因突变原因及对抗病毒感染的生物学机制尚不清楚。本文就Ⅲ型干扰素的生物活性、抗病毒作用机制、抗HIV感染及其基因多态性位点的相关性研究等方面进行综合论述。Type Ⅲ interferon includes IFN-λ1,IFN-λ2,IFN-λ3 and the newly discovered IFN-λ4. It activates a common signal pathway with type I interferon and has similar biological activity. It has anti-virus,antitumor,anti-cell proliferation and immune regulation effects,and plays an important role in anti-HIV infection. At first,it was found that the gene polymorphism of interleukin-28 B is related to the treatment response and spontaneous clearance of HCV infected patients. This correlation analysis was used to predict the therapeutic effect of interferon for HCV infection and guiding clinical medication,which makes the polymorphism site of IL-28 gene become a hot spot. The antiviral commonness of interferon has also attracted scholars′ attention on the correlation between IL-28 gene polymorphism and HIV infection. Recently,many studies have found that genetic variation of IFNL3/4 locus is also associated with disease susceptibility,antiviral immune response and disease progression of AIDS,but the cause of IFNL mutation and its biological mechanism against viral infection remain unclear. This review summarizes the biological activity,antiviral mechanism,anti-HIV infection and the correlation of gene polymorphism sites of type Ⅲ interferon.

关 键 词：Ⅲ型干扰素 HIV 干扰素-λ 单核苷酸多态性 

分 类 号：R392.31[医药卫生—免疫学] R392.32[医药卫生—基础医学]