夫妇双方不同乙型肝炎病毒感染模式对宫腔内人工授精妊娠结局及新生儿情况的影响  

Influence of different HBV infection patterns of couples on pregnancy and neonatal outcomes in intrauterine insemination

作　　者：孙向茹 蔡炳[2] 张丽丽 刘海鹏 罗杰鹏 刘奇志 SUN Xiangru;CAI Bing;ZHANG Lili;LIU Haipeng;LUO Jiepeng;LIU Qizhi(Institute of Reproductive Medicine,Panyu Maternal And Child Care Service Centre of Guangzhou,Guangzhou 511400,China;不详)

机构地区：[1]广州市番禺区妇幼保健院生殖医学科,广州511400 [2]中山大学附属第一医院生殖医学中心,广州510080

出　　处：《实用医学杂志》2021年第23期3041-3046,共6页The Journal of Practical Medicine

基　　金：番禺区科技计划项目(编号:2019-204-46)。

摘　　要：目的探讨夫妇双方不同乙型肝炎病毒(hepatitis B virus,HBV)感染模式对IUI治疗后妊娠结局及出生子代情况的影响。方法回顾性分析我院生殖中心2016年1月-2020年6月接受IUI治疗的周期,根据夫妇双方HBsAg是否为阳性分为4组:A组,仅男方HBsAg阳性;B组,仅女方HBsAg阳性;C组,双方HBsAg均阳性;D组(对照组),双方HBsAg均阴性。比较四组间基本资料、临床结局及出生婴儿情况的差异。结果不同HBV感染模式组妊娠结局与对照组相比差异无统计学意义。出生子代情况方面,男方HBV感染组婴儿剖宫产率高于对照组(67.3%vs. 46.7%,P=0.010),出生婴儿的男女比例高于对照组[(39∶14)vs.(107∶89),P=0.013]。女方及双方HBV感染组出生子代情况与对照组相比无差异。所有出生子代均无畸形及HBV感染。结论 IUI助孕治疗中夫妇双方或一方HBV感染可能不会对妊娠结局产生不利影响,但是男方HBV感染可能增加子代的剖宫产率,并且可能对出生婴儿的性别产生一定的影响。Objective To investigate different HBV infection patterns of couples on the pregnancy and neonatal outcomes in the intrauterine insemination(IUI). Methods A retrospective analysis of IUI treatment from January 2016 to June 2020 in Reproductive Medicine Center in our hospital was conducted. According to whether HBsAg was seropositive or not,the patients were divided into group A(male partners being HBV+);group B(female partners being HBV+);group C(both partners being HBV+)and group D(controls,both partners being HBV-seronegative). The differences of basic parameters,clinical pregnancy and neonatal outcomes among the four groups were compared. Results Compared with that in the control group,there was no difference in pregnancy outcomes in group A,B and C. In terms of the neonatal outcomes,we found the cesarean rate was significantly higher in group A when compared with the control group(67.3% vs. 46.7%,P = 0.010). Moreover,the sex ratio of offspring in group A was statistically higher than that in the control group[(39∶14)vs.(107∶89),P = 0.013].However,there was no difference between group B or C and the control group. All offspring were no deforming and free of HBV infection. Conclusion Different HBV infection patterns of couples have no effect on pregnancy outcomes. However,male partners being HBV infection may increase the risk of cesarean rate,and has certain effect on the sex ratio of newborns.

关 键 词：不同HBV感染模式 宫腔内人工授精 妊娠结局 出生婴儿情况 

分 类 号：R512.66[医药卫生—内科学]