噻托溴铵联合N-乙酰半胱氨酸治疗慢性阻塞性肺疾病稳定期的疗效观察  

Observation on efficacy of tiotropium bromide combined with N-acetyl-L-cysteine in the treatment of chronic obstructive pulmonary disease in stable phase

作　　者：侯双燕 HOU Shuang-yan(Zhuanghe Central Hospital,Zhuanghe 116400,China)

机构地区：[1]辽宁省庄河市中心医院,116400

出　　处：《中国现代药物应用》2021年第23期90-92,共3页Chinese Journal of Modern Drug Application

摘　　要：目的 探究噻托溴铵联合N-乙酰半胱氨酸治疗慢性阻塞性肺疾病稳定期的临床疗效,为临床实践提供理论依据。方法 98例慢性阻塞性肺疾病稳定期患者为研究对象,随机分为参照组与研究组,各49例。参照组应用噻托溴铵治疗,研究组应用噻托溴铵联合N-乙酰半胱氨酸治疗。比较两组治疗前后血气指标及肺功能指标。结果 治疗后,研究组动脉血氧分压(PaO2)为(84.69±6.34)mm Hg(1 mm Hg=0.133 kPa)、血氧饱和度(Sa O2)为(95.78±1.54)%,均优于参照组的(76.85±6.12)mm Hg、(92.12±1.78)%,差异均有统计学意义(P<0.05)。治疗后,研究组第1秒用力呼气容积(FEV1)为(1.83±0.18)L、第1秒用力呼气容积占预计值的百分比(FEV1%pred)为(62.56±8.92)%均优于参照组的(1.61±0.12)L、(51.12±7.73)%,差异均有统计学意义(P<0.05)。结论 慢性阻塞性肺疾病稳定期患者采用噻托溴铵联合N-乙酰半胱氨酸治疗,可有效改善血气指标与肺功能,促进患者恢复,可在临床广泛使用。Objective To investigate the clinical efficacy of tiotropium bromide combined with N-acetyl-L-cysteine in the treatment of chronic obstructive pulmonary disease in stable phase,so as to provide theoretical basis for clinical practice.Methods A total of 98 patients with chronic obstructive pulmonary disease in stable phase as the research subjects were randomly divided into the reference group and the research group,with 49 cases in each group.The reference group was treated with tiotropium bromide,and the research group was treated with tiotropium bromide in combination with N-acetyl-L-cysteine.The blood gas indexes and lung function indexes before and after treatment were compared between the two groups.Results After treatment,the arterial partial pressure of oxygen(PaO_(2))(84.69±6.34)mm Hg(1 mm Hg=0.133 kPa)and the blood oxygen saturation(SaO_(2))(95.78±1.54)% of the research group were better than(76.85±6.12)mm Hg and(92.12±1.78)%of the reference group,and the difference was statistically significant(P<0.05).After treatment,the forced expiratory volume in the 1st second(FEV1)(1.83±0.18)L and FEV1 as a percentage of the predicted value(FEV1% pred)(62.56±8.92)% of the research group were all better than(1.61±0.12)L and(51.12±7.73)% of the reference group,and the differences were statistically significant(P<0.05).Conclusion Tiotropium bromide in combination with N-acetyl-L-cysteine for patients with chronic obstructive pulmonary disease in stable phase can effectively improve the blood gas indicators and lung function,and promote the recovery of patients.It can be widely used in clinical practice.

关 键 词：噻托溴铵 N-乙酰半胱氨酸 慢性阻塞性肺疾病稳定期 

分 类 号：R563.9[医药卫生—呼吸系统]