乙酰半胱氨酸溶液治疗COPD急性加重期的临床疗效观察  

Observation on clinical efficacy of acetylcysteine solution in the treatment of acute exacerbation of COPD

作　　者：潘微微 PAN Wei-wei(Department of Respiratory Pneumoconiosis,Chemical Hospital of Huludao Central Hospital,Huludao 125000,China)

机构地区：[1]葫芦岛市中心医院化工院区呼吸尘肺科,125000

出　　处：《中国现代药物应用》2021年第23期92-95,共4页Chinese Journal of Modern Drug Application

摘　　要：目的 分析对慢性阻塞性肺疾病(COPD)急性加重期患者行乙酰半胱氨酸溶液治疗的临床疗效。方法 70例COPD急性加重期患者,以随机数字表法分为观察组与对照组,各35例。对照组实施基础治疗,观察组实施乙酰半胱氨酸溶液治疗。比较两组治疗效果及治疗前后氧化应激指标、肺功能指标。结果 观察组治疗总有效率97.14%高于对照组的71.43%,差异有统计学意义(P<0.05)治疗后,观察组超氧化物歧化酶(SOD)(79.55±6.03)nU/ml高于对照组的(69.43±5.98)nU/ml,血浆丙二醛(MDA)(5.10±0.43)nmol/ml低于对照组的(6.66±0.54)nmol/ml,差异均有统计学意义(P<0.05)。治疗后,观察组第1秒用力呼气末容积(FEV1)、用力肺活量(FVC)分别为(2.50±0.50)、(1.70±0.28)L,高于对照组的(2.09±0.45)、(1.57±0.25)L,差异有统计学意义(P<0.05)。结论 对COPD急性加重期患者行乙酰半胱氨酸溶液治疗可有效改善患者氧化应激及肺功能,临床应用价值显著。Objective To analyze the clinical efficacy of acetylcysteine solution in the treatment of acute exacerbation of chronic obstructive pulmonary disease(COPD).Methods A total of 70 patients with acute exacerbation of COPD were divided into observation group and control group by random numerical table,with 35 cases in each group.The control group received basic treatment,and the observation group received acetylcysteine solution treatment.The therapeutic effects,oxidative stress indicators and lung function indicators before and after treatment were compared between the two groups.Results The total effective rate of the observation group was 97.14%,which was higher than 71.43%of the control group,and the difference was statistically significant(P<0.05).After treatment,the superoxide dismutase(SOD)(79.55±6.03)nU/ml in the observation group was higher than(69.43±5.98)nU/ml in the control group,and the plasma malondialdehyde(MDA)(5.10±0.43)nmol/ml was lower than(6.66±0.54)nmol/ml in the control group.All the differences were statistically significant(P<0.05).After treatment,the forced expiratory volume in the 1st second(FEV1)and forced vital capacity(FVC)in the observation group were(2.50±0.50)and(1.70±0.28)L,which were higher than(2.09±0.45)and(1.57±0.25)L in the control group,and the difference was statistically significant(P<0.05).Conclusion Acetylcysteine solution can effectively improve the level of oxidative stress and lung function in patients with acute exacerbation of COPD,and has significant value of clinical application.

关 键 词：慢性阻塞性肺疾病急性加重期 乙酰半胱氨酸 氧化应激 肺功能 

分 类 号：R563.9[医药卫生—呼吸系统]