普通肝素与低分子肝素治疗急性肺栓塞的疗效及对血浆肌钙蛋白的影响  

Efficacy of unfractionated heparin and low-molecular-weight heparin on acute pulmonary embolism and its influence on plasma troponin

作　　者：孔萍 KONG Ping(Zhuanghe Central Hospital,Zhuanghe 116400,China)

机构地区：[1]辽宁省庄河市中心医院,116400

出　　处：《中国现代药物应用》2021年第23期95-97,共3页Chinese Journal of Modern Drug Application

摘　　要：目的 分析普通肝素与低分子肝素治疗急性肺栓塞的疗效及对血浆肌钙蛋白的影响,为临床实践提供理论依据。方法 98例急性肺栓塞患者,根据治疗方法不同分为参照组与研究组,每组49例。两组患者均使用华法林治疗,在此基础上,参照组患者给予普通肝素治疗,研究组患者给予低分子肝素治疗。比较两组患者治疗效果及治疗前后血浆肌钙蛋白、纤维蛋白原水平。结果 治疗后,研究组患者血浆肌钙蛋白、纤维蛋白原水平分别为(0.09±0.04)ng/ml、(3.58±0.45)g/L,均低于参照组的(0.32±0.15)ng/ml、(4.12±0.58)g/L,差异具有统计学意义(P<0.05)。研究组患者治疗总有效率为97.96%,高于参照组的85.71%,差异具有统计学意义(P<0.05)。结论 急性肺栓塞患者使用低分子钙素治疗效果显著,可有效降低血浆肌钙蛋白、纤维蛋白原水平,值得临床推广应用。Objective To analyze the effect of unfractionated heparin and low-molecular-weight heparin on acute pulmonary embolism and its influence on plasma troponin,so as to provide theoretical basis for clinical practice.Methods A total of 98 patients with acute pulmonary embolism were divided into the reference group and the research group according to different treatment methods,with 49 cases in each group.Both groups were treated with warfarin.On this basis,patients in the reference group were treated with unfractionated heparin,and patients in the research group were treated with low-molecular-weight heparin.The therapeutic effect and plasma troponin and fibrinogen levels before and after treatment were compared between the two groups.Results After treatment,the levels of plasma troponin and fibrinogen in the research group were(0.09±0.04)ng/ml and(3.58±0.45)g/L,respectively,which were lower than(0.32±0.15)ng/ml,(4.12±0.58)g/L in the reference group,and the difference was statistically significant(P<0.05).The total effective rate of treatment in the research group was 97.96%,which was higher than 85.71%in the reference group,and the difference was statistically significant(P<0.05).Conclusion Low-molecular-weight heparin has significant effect on patients with acute pulmonary embolism,and it can effectively reduce the levels of plasma troponin and fibrinogen,which is worthy of clinical promotion and application.

关 键 词：低分子肝素 急性肺栓塞 普通肝素 血浆肌钙蛋白 纤维蛋白原 

分 类 号：R563.5[医药卫生—呼吸系统]