邻氨基苯甲酸重氮化反应热稳定性及安全评价  

Thermal Stability and Safety Evaluation of Diazotization Reaction in Production of Anthranilic Acid

作　　者：康淑荷[1] 王明强 牛振军 杨永强 KANG Shu-he;WANG Ming-qiang;NIU Zhen-jun;YANG Yong-qiang(College of Chemical Engineering,Northwest Minzu University,Key Laboratory for Utility of Environment-friendly Composite Materials and Biomass in Universities of Gansu Province,Lanzhou 730106,China;Gansu Best Chemical Co.,Ltd.Lanzhou 730000,China;Lanzhou Renewal Urban Construction and Development Co.,Ltd,Lanzhou 730000,China)

机构地区：[1]西北民族大学化工学院环境友好复合材料及生物质利用甘肃省高校重点实验室,甘肃兰州730030 [2]甘肃贝斯化工有限公司,甘肃兰州730000 [3]兰州更新城市建设发展有限公司,甘肃兰州730000

出　　处：《西北民族大学学报（自然科学版）》2021年第4期7-14,共8页Journal of Northwest Minzu University(Natural Science)

基　　金：西北民族大学中央高校创新团队项目(31920190018,31920190013);甘肃贝斯化工有限公司项目(BSHG201903001)。

摘　　要：对邻氨基苯甲酸重氮化反应进行热稳定性DSC、反应量热RC1、重氮化反应完成液的绝热量热测定,并从分解热、严重度、可能性、矩阵风险评估和反应工艺危险度五个方面对该反应进行了反应安全风险评估.实验结果表明,重氮化反应完成液分解热为188.44 J/g,反应过程中ΔT_(ad)为25.9 K,T_(p)为2℃、MTT为100℃、T_(D24)为29.9℃,MTSR为22.5℃,故反应过程T_(p)<MTSR<T_(D24)<MTT.邻氨基苯甲酸重氮化反应过程的反应安全风险等级为2级.该工艺条件下的反应存在潜在分解风险,因此邻氨基苯甲酸重氮化工业生产必须配备自动控制系统(DCS)和安全切断系统(SIS).由于MTSR(22.5℃)和T_(D24)(29.9℃)相差很近,反应过程中应该严格控制反应温度、滴加速度等相关参数,以防工艺危险度级别发生突变而引起安全措施不到位,导致安全事故发生.Thermal stability DSC,reaction calorimetry RC1,adiabatic heat measurement of the completion solution of diazonium reaction were performed on the diazotization reaction of anthranilic acid.The reaction safety risk was evaluated from decomposition heat,severity,possibility,matrix risk assessment and reaction process risk degree.Experimental results showed that the heat of decomposition of the diazotization reaction liquid was 188.44 J/g,theΔT_(ad)was 25.9 K,the T_(p) was 2℃,the MTT was 100℃,the T_(D24) was 29.9℃,and the MTSR was 22.5℃,so T_(p)<MTSR<T_(D24)<MTT in the reaction process.The reaction safety risk level of anthranilic acid diazotization reaction was level 2,and the reaction under this process condition had potential decomposition risk.The industrial production of diazotization of o-aminobenzoic acid must be equipped with an automatic control system(DCS)and safety shutdown system(SIS).Because the difference between MTSR(22.5℃)and T_(D24)(29.9℃)was too close,the reaction temperature,dropping speed and other related parameters should be strictly controlled in the reaction process to prevent sudden changes in the process risk level,which may cause the safety measures not to be in place,resulting in happening safety the accident.

关 键 词：邻胺基苯甲酸 反应热 重氮化 安全评价 

分 类 号：TH3[机械工程—机械制造及自动化]