微量元素检测在免疫性不孕症诊断中的意义  

The Significance of Trace Element Detection in Diagnosis of Immune Infertility

作　　者：安利峰[1] 慈彩虹 尚立娜 胜利[1] AN Li-feng;CI Cai-hong;SHANG Li-na;SHENG Li(Department of Medicine,Northwest Minzu University,Lanzhou 730030,China)

机构地区：[1]西北民族大学医学部,甘肃兰州730030

出　　处：《西北民族大学学报（自然科学版）》2021年第4期37-40,共4页Journal of Northwest Minzu University(Natural Science)

基　　金：西北民族大学引进人才项目(xbmuyjrc201630)。

摘　　要：目的:探讨免疫性不孕症患者自身抗体产生与微量元素的相关性,为免疫性不孕症的诊治提供新的思路.方法:用原子吸收光谱测定法检测35例免疫性不孕症患者(实验组)和25例健康女性(对照组)的血清中Ca、Fe、Zn、Cu水平,用酶联免疫吸附试验(ELISA)检测AhCGAb、AsAb、AoAb、EmAb,并检测两者的相关性.结果:不孕症患者组血清中Ca和Fe含量降低,但与对照组没有显著性差异(P>0.05),而Zn和Cu含量增高,与对照组比较差异性显著(P<0.01),Cu与AhCGAb、AsAb、AoAb、EmAb的产生呈正相关(P<0.01),而Ca、Fe、Zn则与AhCGAb、AsAb、AoAb、EmAb的产生无相关性.结论:不孕症患者血清中微量元素发生改变,其中Cu含量增加且与自身抗体产生呈正相关,所以微量元素检测可作为免疫性不孕症诊治新方法.Objective To provide a new diagnostic approach for immunologic infertility by investigating the correlation of autoantibodies and trace elements from immunologically infertile patients.Methods The expression levels of Ca, Fe, Zn and Cu were detected by atomic absorption spectrometry.The AhCGAb, AsAb, AOAb, EMAb were detected by enzyme-linked immunosorbent assay(ELISA).Results The expression levels of Ca and Fe were decreased in the serum of the infertility group without significant difference in comparison with control group(P>0.05).The expression levels of Zn and Cu were significantly increased as compared to the control group(P<0.01).Cu was positively correlated to the generation of AhCGAb, AsAb, AoAb and EmAb(P<0.01).Ca, Fe and Zn had no correlation with the production of AhCGAb, AsAb, AoAb and EmAb.Conclusion The serum trace elements in infertility patients were changed, and the content of Cu was increased and positively correlated with the production of autoantibodies.So detecting the trace elements has become the new index of diagnosis and treatment of immune infertility.

关 键 词：不孕症 抗体 微量元素 相关性 

分 类 号：R71[医药卫生—妇产科学]